Stem cell regulation: Implications when differentiated cells regulate symmetric stem cell division
Journal article, Peer reviewed
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Original versionHøyem, M.R. et al (2015) Stem cell regulation: Implications when differentiated cells regulate symmetric stem cell division. Journal of Theoretical Biology, 380:203-219 10.1016/j.jtbi.2015.05.009
We use a mathematical model to show that if symmetric stem cell division is regulated by differentiated cells, then changes in the population dynamics of the differentiated cells can lead to changes in the population dynamics of the stem cells. More precisely, the relative fi tness of the stem cells can be affected by modifying the death rate of the differentiated cells. This result is interesting because stem cells are less sensitive than differentiated cells to environmental factors, such as medical therapy. Our result implies that stem cells can be manipulated indirectly by medical treatments that target the differentiated cells.
Published by Elsevier Ltd. This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).