Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis
Linster, Eric; Stephan, Iwona; Bienvenut, Willy V.; Maple-Grødem, Jodi; Myklebust, Line Merethe; Huber, Monika; Reichelt, Michael; Sticht, Carsten; Møller, Simon Geir; Meinnel, Thierry; Arnesen, Thomas; Giglione, Carmela; Hell, Rüdiger; Wirtz, Markus
Journal article, Peer reviewed
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http://hdl.handle.net/11250/2381953Utgivelsesdato
2015-07Metadata
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Originalversjon
Linster, E., et al. (2015) Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis. Nature Communications, 6:7640 10.1038/ncomms8640Sammendrag
N-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats) is among
the most common protein modifications in eukaryotes, but its significance is still enigmatic.
Here we characterize the plant NatA complex and reveal evolutionary conservation of NatA
biochemical properties in higher eukaryotes and uncover specific and essential functions of
NatA for development, biosynthetic pathways and stress responses in plants. We show
that NTA decreases significantly after drought stress, and NatA abundance is rapidly
downregulated by the phytohormone abscisic acid. Accordingly, transgenic downregulation of
NatA induces the drought stress response and results in strikingly drought resistant plants.
Thus, we propose that NTA by the NatA complex acts as a cellular surveillance mechanism
during stress and that imprinting of the proteome by NatA is an important switch for
the control of metabolism, development and cellular stress responses downstream of
abscisic acid.
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