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dc.contributor.authorBreitve, Monica H.
dc.contributor.authorHynninen, Minna J.
dc.contributor.authorBrønnick, Kolbjørn
dc.contributor.authorChwiszczuk, Luiza J.
dc.contributor.authorAuestad, Bjørn H.
dc.contributor.authorAarsland, Dag
dc.contributor.authorRongve, Arvid
dc.identifier.citationBreitve, M.H et al. (2015) A longitudinal study of anxiety and cognitive decline in dementia with Lewy bodies and Alzheimer’s disease. Alzheimer's Research & Therapy, 8:3nb_NO
dc.descriptionThis article was originally published in the journal "Alzheimer's Research & Therapy". This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.nb_NO
dc.description.abstractBackground Anxiety in dementia is common but not well studied. We studied the associations of anxiety longitudinally in Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Methods In total, 194 patients with a first-time diagnosis of dementia were included (n = 122 patients with AD, n = 72 patients with DLB). Caregivers rated the patients’ anxiety using the Neuropsychiatric Inventory, and self-reported anxiety was assessed with the anxiety and tension items on the Montgomery–Åsberg Depression Rating Scale. The Mini Mental State Examination was used to assess cognitive outcome, and the Clinical Dementia Rating (CDR)-Global and CDR boxes were used for dementia severity. Linear mixed effects models were used for longitudinal analysis. Results Neither in the total sample nor in AD or DLB was caregiver-rated anxiety significantly associated with cognitive decline or dementia severity over a 4-year period. However, in patients with DLB, self-reported anxiety was associated with a slower cognitive decline than in patients with AD. No support was found for patients with DLB with clinical anxiety having a faster decline than patients with DLB without clinical anxiety. Over the course of 4 years, the level of anxiety declined in DLB and increased in AD. Conclusions Anxiety does not seem to be an important factor for the rate of cognitive decline or dementia severity over time in patients with a first-time diagnosis of dementia. Further research into anxiety in dementia is needed.nb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 3.0 Norge*
dc.subjectAlzheimers sykdomnb_NO
dc.subjectdementia with Lewy bodiesnb_NO
dc.subjectdemens med Lewy-legemer
dc.titleA longitudinal study of anxiety and cognitive decline in dementia with Lewy bodies and Alzheimer’ s diseasenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holder© 2016 Breitve et al.nb_NO
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750nb_NO
dc.source.journalAlzheimer's Research & Therapynb_NO

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Navngivelse 3.0 Norge
Except where otherwise noted, this item's license is described as Navngivelse 3.0 Norge