Recent Submissions

  • Sensitivity analysis of a pathway with respect to fast and small temperature change 

    Zakhartsev, Maksim; Ruoff, Peter (Journal article; Peer reviewed, 2019)
    Temperature affects all enzymes simultaneously in a metabolic system. The enzyme concentration in a biochemical system can be considered as invariant under fast and small temperature change. Therefore, the total sensitivity ...
  • Low-concentration salting of cod loins: The effect on biochemical properties and predicted water retention during heating 

    Blikra, Marthe Jordbrekk; Jessen, Flemming; Feyissa, Aberham H.; Vaka, Mette Risa; Skipnes, Dagbjørn (Journal article; Peer reviewed, 2019-10)
    Low levels of salt are frequently used to increase flavor and water retention in cod. This alters the biochemical properties of cod during heating. In this paper, properties needed to mathematically model moisture transfer ...
  • The crystal structure of haemoglobin from Atlantic cod 

    Helland, Ronny; Bjørkeng, Eva Katrin; Rothweiler, Ulli; Sydnes, Magne Olav; Pampanin, Daniela Maria (Journal article; Peer reviewed, 2019-06)
    The crystal structure of haemoglobin from Atlantic cod has been solved to 2.54 Å resolution. The structure consists of two tetramers in the crystallographic asymmetric unit. The structure of haemoglobin obtained from one ...
  • Combinatory microRNA serum signatures as classifiers of Parkinson's disease 

    Patil, Ketan S.; Basak, Indranil; Dalen, Ingvild; Hoedt, Esthelle; Lange, Johannes; Lunde, Kristin Aaser; Liu, Ying; Tysnes, Ole-Bjørn; Forsgren, Lars; Aarsland, Dag; Neubert, Thomas A.; Larsen, Jan Petter; Alves, Guido Werner; Møller, Simon Geir (Journal article; Peer reviewed, 2019-04)
    As current clinical diagnostic protocols for Parkinson's disease (PD) may be prone to inaccuracies there is a need to identify and validate molecular biomarkers, such as circulating microRNAs, which will complement current ...
  • Kinase chemodiversity from the Arctic: the breitfussins 

    Østnes Hansen, Kine; Andersen, Jeanette hammer; Bayer, Annette; Pandey, Sunil Kumar; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe; Klebl, Bert; Eickhoff, Jan; Haug, Bengt Erik; Isaksson, Johan; Hansen, Espen (Journal article; Peer reviewed, 2019-10)
    In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C–H (3 ...
  • Alexeeva, M., Moen, M.N., Grøsvik, K. et al (2018) Excision of uracil from DNA by hSMUG1 includes strand incision and processing. 

    Moen, Marivi Nabong; Grøsvik, Kristin; Kirpekar, Finn; Tesfahun, Almaz Nigatu; Ruoff, Peter; Klungland, Arne; Bjelland, Svein (Journal article; Peer reviewed, 2018-11)
    Uracil arises in DNA by hydrolytic deamination of cytosine (C) and by erroneous incorporation of deoxyuridine monophosphate opposite adenine, where the former event is devastating by generation of C → thymine transitions. ...
  • Homeostatic controllers compensating for growth and perturbations 

    Ruoff, Peter; Agafonov, Oleg; Tveit, Daniel Myklatun; Thorsen, Kristian; Drengstig, Tormod (Journal article; Peer reviewed, 2019-08)
    Cells and organisms have developed homeostatic mechanisms which protect them against a changing environment. How growth and homeostasis interact is still not well understood, but of increasing interest to the molecular and ...
  • Food Microstructure and Fat Content Affect Growth Morphology, Growth Kinetics, and Preferred Phase for Cell Growth of Listeria monocytogenes in Fish-Based Model Systems 

    Verheyen, Davy; Xu, Xiang Ming; Govaert, Marlies; Baka, Maria; Skåra, Torstein; Van Impe, Jan FM (Journal article; Peer reviewed, 2019-06)
    Food microstructure significantly affects microbial growth dynamics, but knowledge concerning the exact influencing mechanisms at a microscopic scale is limited. The food microstructural influence on Listeria monocytogenes ...
  • Excessive Daytime Sleepiness and REM Sleep Behavior Disorders in Parkinson's Disease: A Narrative Review on Early Intervention With Implications to Neuroprotection 

    Gjerstad, Michaela D; Alves, Guido Werner; Maple-Grødem, Jodi (Journal article; Peer reviewed, 2018-11)
    Sleep contributes to the consolidation of our memory and facilitates learning. Short term sleep deprivation temporarily reduces mnestic capacity, whereas long lasting sleep deprivation is associated with structural changes ...
  • Gastrointestinal microbial community changes in Atlantic cod (Gadus morhua) exposed to crude oil 

    Bagi, Andrea; Riiser, Even Sannes; Molland, Hilde Steine; Star, Bastiaan; Haverkamp, Thomas Hendricus Augustus; Sydnes, Magne Olav; Pampanin, Daniela Maria (Journal article; Peer reviewed, 2018-04)
    Background The expansion of offshore oil exploration increases the risk of marine species being exposed to oil pollution in currently pristine areas. The adverse effects of oil exposure through toxic properties of polycyclic ...
  • Modeling 3D cancer growth and extracellular matrix properties in vitro 

    Ahmad, Hina (Master thesis, 2018-08-15)
    Background: Cancer can be defined as loss of normal behavior of cellular components thus losing tissue organization and giving rise to a tumor microenvironment (TME). Increased matrix stiffness, strain and elevated ...
  • Design, synthesis and antitumor evaluation of novel pyrazolopyrimidines and pyrazoloquinazolines 

    Mady, Mohamed Fawzy Hamed Attia; El-Naggar, Mohamed; Hassan, Ashraf S.; Awad, Hanem M. (Journal article; Peer reviewed, 2018-05)
    A series of N-aryl-7-aryl-pyrazolo[1,5-a]pyrimidines 18a–u and N-aryl-pyrazolo[1,5-a] quinazolines 25a–c were designed and synthesized via the reaction of 5-aminopyrazoles 11a–c with enaminones 12a–g or 19, respectively. ...
  • Multi-fluid CFD analysis in Process Engineering 

    Hjertager, Bjørn H (Journal article; Peer reviewed, 2017)
    An overview of modelling and simulation of flow processes in gas/particle and gas/liquid systems are presented. Particular emphasis is given to computational fluid dynamics (CFD) models that use the multi-dimensional ...