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  • Mitotic activity index and CD25+ lymphocytes predict risk of stage progression in non-muscle invasive bladder cancer 

    Lillesand, Melinda; Kvikstad, Vebjørn; Mangrud, Målfrid Ok; Gudlaugsson, Einar; Van Diermen, Bianca; Skaland, Ivar; Baak, Johannes Peter A; Janssen, Emiel (Peer reviewed; Journal article, 2020-06)
    In urothelial cell type non-muscle invasive urinary bladder carcinoma, TNM stage and WHO grade are widely used to classify patients into low and high-risk groups for prognostic and therapeutic decision-making. However, ...
  • 1,4-Dideoxy-1,4-imino‑D‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitors 

    Haarr, Marianne Bore; Lopez, Oscar; Pejov, Ljupcho; Fernandez-Bolanos, Jose G.; Lindback, Emil; Sydnes, Magne Olav (Peer reviewed; Journal article, 2020-07)
    The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase ...
  • Synthesis of trans-dihydronaphthalene-diol and evaluation of their use as standards for PAH metabolite analysis in fish bile by GC-MS 

    Vaaland, Ingrid Caroline; Pampanin, Daniela Maria; Sydnes, Magne Olav (Peer reviewed; Journal article, 2020-05)
    Phenols and trans-1,2-dihydro-1,2-diols are metabolites commonly formed in vivo in fish upon exposure to polycyclic aromatic hydrocarbons (PAHs). These metabolites are excreted via the bile and gas chromatography-mass ...
  • Frequency switching between oscillatory homeostats and the regulation of p53 

    Ruoff, Peter; Nishiyama, Nobuaki (Peer reviewed; Journal article, 2020-05)
    Homeostasis is an essential concept to understand the stability of organisms and their adaptive behaviors when coping with external and internal assaults. Many hormones that take part in homeostatic control come in ...
  • Understanding the role of the shrimp gut microbiome in health and disease 

    Holt, Corey; Bass, David; Stentiford, Grant D.; van der Giezen, Mark (Peer reviewed; Journal article, 2020-04)
    With rapid increases in the global shrimp aquaculture sector, a focus on animal health during production becomes ever more important. Animal productivity is intimately linked to health, and the gut microbiome is becoming ...
  • Prognostic value and reproducibility of different microscopic characteristics in the WHO grading systems for pTa and pT1 urinary bladder urothelial carcinomas 

    Kvikstad, Vebjørn; Mangrud, Målfrid Ok; Gudlaugsson, Einar; Dalen, Ingvild; Espeland, Hans; Baak, Jan P.A.; Janssen, Emiel (Peer reviewed; Journal article, 2019-08)
    Background: European treatment guidelines for pTa and pT1 urinary bladder urothelial carcinoma depend highly on stage and WHO-grade. Both the WHO73 and the WHO04 grading systems show some intra- and interobserver variability. ...
  • Energy optimization of biological wastewater treatment using rotating belt filters upstream BNR 

    Razafimanantsoa, Valeri Aristide (Doctoral thesis, 2020-04)
    Treatment of wastewater to acceptable permit standards requires energy, mostly as electricity. The typical energy demand for various wastewater treatment technologies vary from 0.30 to 1.50 kWh/m3 of treated water. For ...
  • A systems biology approach to cellular homeostasis, volume changes and regulation of metabolism 

    Fjeld, Gunhild (PhD thesis UiS;509, Doctoral thesis, 2020-04)
    Cells need to respond to a vast range of different disturbances and changes over small and large time scales. This can be disturbances in the form of molecules used to fight infectious states, changes in growth patterns, ...
  • Granular sludge bed processes in anaerobic digestion of particle-rich substrates 

    Tassew, Fasil Ayelegn; Bergland, Wenche Hennie; Dinamarca, Carlos; Kommedal, Roald; Bakke, Rune (Peer reviewed; Journal article, 2019-07)
    Granular sludge bed (GSB) anaerobic digestion (AD) is a well-established method for efficient wastewater treatment, limited, however, by the wastewater particle content. This review is carried out to investigate how and ...
  • Nitrogen retention in mature constructed wetlands 

    Ims, Kine (Master thesis, 2019-06-14)
    Constructed wetlands are created for the purpose of treating anthropogenic discharges, such as agricultural and urban runoff to reduce the potential of undesirable effects in receiving waters. Leikvollbekken is a mature ...
  • Matkjemiens rolle i å skape sunne og kritiske elever 

    Boye, Amalie Andersen (Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-06-12)
    The aim of the study was to determine the extent to which dietary education and the food chemistry in secondary schools affect the pupils' attitudes and actions in relation to diet. To find out more about this, the study ...
  • Sensitivity analysis of a pathway with respect to fast and small temperature change 

    Zakhartsev, Maksim; Ruoff, Peter (Journal article; Peer reviewed, 2019)
    Temperature affects all enzymes simultaneously in a metabolic system. The enzyme concentration in a biochemical system can be considered as invariant under fast and small temperature change. Therefore, the total sensitivity ...
  • Effects of rockfill dams and rock dumps on downstream water chemistry 

    Stoelen, Christine (Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-10-28)
    A number of potential negative effects on aquatic environments are associated with rockfills. However, in southwestern Norway, lakes and rivers downstream from large rockfills were among the very few sites where trout ...
  • Contents of organic acids in tomato fruits as a function of light and nutrition 

    Pettersen, Lea Zalar (Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-06-10)
    Tomato (Solanum lycopersicum) is one of the most consumed vegetables in the world. It is a source of antioxidants, minerals and vitamins, and has many beneficial effects on health. In the last decades, the taste properties ...
  • Low-concentration salting of cod loins: The effect on biochemical properties and predicted water retention during heating 

    Blikra, Marthe Jordbrekk; Jessen, Flemming; Feyissa, Aberham H.; Vaka, Mette Risa; Skipnes, Dagbjørn (Journal article; Peer reviewed, 2019-10)
    Low levels of salt are frequently used to increase flavor and water retention in cod. This alters the biochemical properties of cod during heating. In this paper, properties needed to mathematically model moisture transfer ...
  • The crystal structure of haemoglobin from Atlantic cod 

    Helland, Ronny; Bjørkeng, Eva Katrin; Rothweiler, Ulli; Sydnes, Magne Olav; Pampanin, Daniela Maria (Journal article; Peer reviewed, 2019-06)
    The crystal structure of haemoglobin from Atlantic cod has been solved to 2.54 Å resolution. The structure consists of two tetramers in the crystallographic asymmetric unit. The structure of haemoglobin obtained from one ...
  • Combinatory microRNA serum signatures as classifiers of Parkinson's disease 

    Patil, Ketan S.; Basak, Indranil; Dalen, Ingvild; Hoedt, Esthelle; Lange, Johannes; Lunde, Kristin Aaser; Liu, Ying; Tysnes, Ole-Bjørn; Forsgren, Lars; Aarsland, Dag; Neubert, Thomas A.; Larsen, Jan Petter; Alves, Guido Werner; Møller, Simon Geir (Journal article; Peer reviewed, 2019-04)
    As current clinical diagnostic protocols for Parkinson's disease (PD) may be prone to inaccuracies there is a need to identify and validate molecular biomarkers, such as circulating microRNAs, which will complement current ...
  • Kinase chemodiversity from the Arctic: the breitfussins 

    Østnes Hansen, Kine; Andersen, Jeanette hammer; Bayer, Annette; Pandey, Sunil Kumar; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe; Klebl, Bert; Eickhoff, Jan; Haug, Bengt Erik; Isaksson, Johan; Hansen, Espen (Journal article; Peer reviewed, 2019-10)
    In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C–H (3 ...
  • Alexeeva, M., Moen, M.N., Grøsvik, K. et al (2018) Excision of uracil from DNA by hSMUG1 includes strand incision and processing. 

    Moen, Marivi Nabong; Grøsvik, Kristin; Kirpekar, Finn; Tesfahun, Almaz Nigatu; Ruoff, Peter; Klungland, Arne; Bjelland, Svein (Journal article; Peer reviewed, 2018-11)
    Uracil arises in DNA by hydrolytic deamination of cytosine (C) and by erroneous incorporation of deoxyuridine monophosphate opposite adenine, where the former event is devastating by generation of C → thymine transitions. ...
  • Homeostatic controllers compensating for growth and perturbations 

    Ruoff, Peter; Agafonov, Oleg; Tveit, Daniel Myklatun; Thorsen, Kristian; Drengstig, Tormod (Journal article; Peer reviewed, 2019-08)
    Cells and organisms have developed homeostatic mechanisms which protect them against a changing environment. How growth and homeostasis interact is still not well understood, but of increasing interest to the molecular and ...

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