• mRNA Expression of EGFP by lipid nanoparticles 

  Motland, Bjørnar Naaden (Bachelor thesis, 2024)

  Two scientists, Katalin Karikó and Drew Weismann of Pennsylvania state university began research on mRNA as protein replacement therapeutics in the 90’s, but due to the mRNA’s immunogenicity it could not be used. However, ...

• Destabilization of crude oil sludges by chemical and mechanical treatment 

  Mauritzen, Hanne (Master thesis, 2022)

  The demand for petroleum is still increasing. As a result, various wastes are generated during exploration and production, even though strict rules and regulations are applied to oil and gas industries to optimize waste ...

• Extracellular vesicles as a potential source of tumor-derived DNA in advanced pancreatic cancer 

  Lapin, Morten; Tjensvoll, Kjersti; Nedrebø, Karoline; Taksdal, Eline; Janssen, Hans; Gilje, Bjørnar; Nordgård, Oddmund (Peer reviewed; Journal article, 2023)

  Tumor-derived extracellular vesicles (EVs) are reported to contain nucleic acids, including DNA. Several studies have highlighted the potential of EV-derived DNA (evDNA) as a circulating biomarker, even demonstrating that ...

• Inflammatory biomarkers in newly diagnosed patients with Parkinson’s disease and related neurodegenerative disorders 

  Pedersen, Camilla Christina; Ushakova, Anastasia; Skogseth, Ragnhild Eide; Alves, Guido Werner; Tysnes, Ole-Bjørn; Aarsland, Dag; Lange, Johannes; Maple-Grødem, Jodi (Peer reviewed; Journal article, 2023)

  Background and Objectives Neuroinflammation contributes to Parkinson disease (PD) pathology, and inflammatory biomarkers may aid in PD diagnosis. Proximity extension assay (PEA) technology is a promising method for multiplex ...

• From Research to Clinical Diagnostics: Developing and Validating Biomarkers and Artificial Intelligence for Pathology 

  Rewcastle, Emma (PhD thesis UiS;, Doctoral thesis, 2024)

  In 2021, digital pathology was deployed in the hospitals of the western health region of Norway. Histological tissue specimens previously viewed under the microscope on glass slides, are now being scanned, and whole slide ...

• Mapping the Antimicrobial Activity of Indoloquinoline and Neocryptolepine Analogues 

  Håheim, Katja Stangeland; Albrigtsen, Marte; Helland, Kirsti; Andersen, Jeanette Hammer; Sydnes, Magne Olav (Peer reviewed; Journal article, 2023)

• Subcellular localization and therapeutic efficacy of polymeric micellar nanoparticles encapsulating bedaquiline for tuberculosis treatment in zebrafish 

  Bhandari, Madhavi; Soria-Carrera, Héctor; Wohlmann, Jens; Dal, Nils-Jørgen; de la Fuente, Jesús M.; Martín-Rapún, Rafael; Griffiths, Gareth Wyn; Fenaroli, Federico (Peer reviewed; Journal article, 2023)

  The combination drug regimens that have long been used to treat tuberculosis (TB), caused by Mycobacterium tuberculosis, are fraught with problems such as frequent administration, long duration of treatment, and harsh ...

• Impact of KRAS and BRAF mutations on treatment efficacy and survival in high-grade gastroenteropancreatic neuroendocrine neoplasms 

  Elvebakken, Hege; Hjortland, Geir Olav; Garresori, Herish; Andresen, Per Arne; Janssen, Emiel; Vintermyr, Olav Karsten; Lothe, Inger Marie Bowitz; Sorbye, Halfdan (Peer reviewed; Journal article, 2023)

  High-grade gastroenteropancreatic neuroendocrine neoplasms (HG GEP-NEN) typically disseminate early. Treatment of metastatic disease has limited benefit and prognosis is generally discouraging. Data on the clinical impact ...

• Cognitive Profile in Parkinson’s Disease Dementia Patients with Low versus Normal Cerebrospinal Fluid Amyloid Beta 

  Tufekcioglu, Zeynep; Lange, Johannes; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Emre, Murat (Peer reviewed; Journal article, 2023)

  Introduction: In patients with Parkinson’s disease (PD), low cerebrospinal fluid (CSF) amyloid beta 1-42 (Ab42) at baseline is the most consistent CSF biomarker as a risk factor for developing dementia. Low CSF Ab42 is, ...

• Regiodivergent Synthesis of 11H-Indolo[3,2-c]quinolines and Neocryptolepine from a Common Starting Material 

  Håheim, Katja Stangeland; Lund, Bjarte Aarmo; Sydnes, Magne Olav (Peer reviewed; Journal article, 2023)

  A large number of diversely functionalized analogs of the bioactive natural products neocryptolepine and isocryptolepine have been prepared from a series of 3-bromoquinoline derivatives. The neocryptolepines were obtained ...

• Exploring Pathogenicity in Blastocystis ST7 and ST4: A comparative analysis of virulence factors from known intestinal parasites for pathogenicity assessment in Blastocystis spp. 

  Holand, Ine (Master thesis, 2023)

  Blastocystis, a unicellular parasite found in the human gastrointestinal tract, has been a topic of study due to its potential pathogenicity. This study identified potential virulence factors within Blastocystis subtypes ...

• Phosphonated Polyetheramine-Coated Superparamagnetic Iron Oxide Nanoparticles for Inhibition of Oilfield Scale 

  Mady, Mohamed Fawzy Hamed Attia; Alkaraly, Ali Hasan Saber; Kelland, Malcolm Andrew (Peer reviewed; Journal article, 2023)

  Oilfield scale is one of the significant problems in hydrocarbon production in the oil and gas industry. Many research groups have attempted to develop greener chemicals to meet environmental regulations. Magnetic nanoparticles ...

• Long-term operation of an anaerobic bioreactor effluent gravity driven membrane system 

  Bredal, Mikal (Master thesis, 2023)

  Currently, anaerobic treatment technology stands out as a viable solution for wastewater treatment due to its minimal carbon footprint. The key advantage lies in its capacity to directly convert organics into methane, ...

• Changes in Plasma Pyruvate and TCA Cycle Metabolites upon Increased Hepatic Fatty Acid Oxidation and Ketogenesis in Male Wistar Rats 

  Dankel, Simon Nitter; Kalleklev, Tine-Lise; Tungland, siri Lunde; Stafsnes, Marit Hallvardsdotter; Bruheim, Per; Aloysius, Thomas Aquinas; Lindquist, Carine; SKORVE, JON; Nygård, Ottar Kjell; Madsen, Lise; Bjørndal, Bodil; Sydnes, Magne Olav; Berge, Rolf Kristian (Peer reviewed; Journal article, 2023)

  Altered hepatic mitochondrial fatty acid β-oxidation and associated tricarboxylic acid (TCA) cycle activity contributes to lifestyle-related diseases, and circulating biomarkers reflecting these changes could have disease ...

• Homologous Recombination Deficiency Across Subtypes of Primary Breast Cancer 

  Yndestad, Synnøve; Engebrethsen, Christina; Herencia-Ropero, A.; Nikolaienko, Oleksii; Vintermyr, Olav Karsten; Lillestøl, Reidun Kristine; Minsaas, Laura; Leirvaag, Beryl; Iversen, Gjertrud Titlestad; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Aase, Hildegunn Siv; Aas, Turid; Gudlaugsson, Einar; Llop-Guevara, Alba; Serra, Violeta; Janssen, Emiel; Lønning, Per Eystein; Knappskog, Stian; Eikesdal, Hans Petter (Peer reviewed; Journal article, 2023)

  Purpose Homologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of HRD in non-TNBC to ...

• Evolutionary analysis of cellular reduction and anaerobicity in the hyper-prevalent gut microbe Blastocystis 

  Záhonová, Kristína; Low, Ross S.; Warren, Christopher J.; Cantoni, Diego; Herman, Emily K.; Yiangou, Lyto; Ribeiro, Cláudia A.; Phanprasert, Yasinee; Brown, Ian R.; Rueckert, Sonja; Baker, Nicola L.; Tachezy, Jan; Betts, Emma L.; Gentekaki, Eleni; van der Giezen, Mark; Clark, C. Graham; Jackson, Andrew P.; Dacks, Joel B.; Tsaousis, Anastasios D. (Peer reviewed; Journal article, 2023)

  Blastocystis is the most prevalent microbial eukaryote in the human and animal gut, yet its role as commensal or parasite is still under debate. Blastocystis has clearly undergone evolutionary adaptation to the gut environment ...

• Π-Π interactions stabilize PeptoMicelle-based formulations of Pretomanid derivatives leading to promising therapy against tuberculosis in zebrafish and mouse models 

  Dal, Nils-Jørgen; Schäfer, Gabriela; Thompson, Andrew; Schmitt, Sascha; Redinger, Natalja; Alonso Rodriguez, Noelia; Johann, Kerstin; Ojong, Jessica; Wohlmann, Jens; Best, Andreas; Koynov, Kaloian; Zentel, Rudolf; Schaible, Ulrich E.; Griffiths, Gareth Wyn; Barz, Matthias; Fenaroli, Federico (Peer reviewed; Journal article, 2023)

  Tuberculosis is the deadliest bacterial disease globally, threatening the lives of millions every year. New antibiotic therapies that can shorten the duration of treatment, improve cure rates, and impede the development ...

• Modular Synthesis of Semiconducting Graft Copolymers to Achieve “Clickable” Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting 

  Creamer, Adam; Fiego, Alessandra Lo; Agliano, Alice; Prados-Martin, Lino; Høgset, Håkon; Najer, Adrian; Richards, Daniel A.; Wojciechowski, Jonathan P.; Foote, James E. J.; Kim, Nayoung; Monahan, Amy; Tang, Jiaqing; Shamsabadi, André; Rochet, Léa N. C.; Thanasi, Ioanna A.; de la Ballina, Laura R; Rapley, Charlotte L.; Turnock, Stephen; Love, Elizabeth A.; Bugeon, Laurence; Dallman, Margaret J.; Heeney, Martin; Kramer-Marek, Gabriela; Chudasama, Vijay; Fenaroli, Federico; Stevens, Molly M. (Peer reviewed; Journal article, 2023)

  Semiconducting polymer nanoparticles (SPNs) are explored for applications in cancer theranostics because of their high absorption coefficients, photostability, and biocompatibility. However, SPNs are susceptible to aggregation ...

• Comprehensive ctDNA Measurements Improve Prediction of Clinical Outcomes and Enable Dynamic Tracking of Disease Progression in Advanced Pancreatic Cancer 

  Lapin, Morten; Edland, Karin Hestnes; Tjensvoll, Kjersti; Oltedal, Satu; Austdal, Marie; Garresori, Herish; Rozenholc, Yves; Gilje, Bjørnar; Nordgård, Oddmund (Peer reviewed; Journal article, 2023)

  Purpose: Circulating tumor DNA (ctDNA) has emerged as a promising tumor-specific biomarker in pancreatic cancer, but current evidence of the clinical potential of ctDNA is limited. In this study, we used comprehensive ...

• Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer 

  Page, David B; Broeckx, Glenn; Jahangir, Chowdhury Arif; Verbandt, Sara; Gupta, Rajarsi R; Thagaard, Jeppe; Khiroya, Reena; Kos, Zuzana; Abduljabbar, Khalid; Acosta Haab, Gabriela; Acs, Balazs; Akturk, Guray; Almeida, Jonas S; Alvarado-Cabrero, Isabel; Azmoudeh-Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Bellolio, Enrique R; Bheemaraju, Vydehi; Blenman, Kim RM; Botinelly Mendonça Fujimoto, Luciana; Bouchmaa, Najat; Burgues, Octavio; Cheang, Maggie Chon U; Ciompi, Francesco; Cooper, Lee AD; Coosemans, An; Corredor, Germán; Dantas Portela, Flavio Luis; Deman, Frederik; Demaria, Sandra; Dudgeon, Sarah N; Elghazawy, Mahmoud; Ely, Scott; Fernandez-Martín, Claudio; Fineberg, Susan; Fox, Stephen B; Gallagher, William M; Giltnane, Jennifer M; Gnjatic, Sacha; Gonzalez-Ericsson, Paula I; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G; Harbhajanka, Aparna; Hardas, Alexandros; Hart, Steven N; Hartman, Johan; Hewitt, Stephen; Hida, Akira I; Horlings, Hugo M; Husain, Zaheed; Hytopoulos, Evangelos; Irshad, Sheeba; Janssen, Emiel; Kahila, Mohamed; Kataoka, Tatsuki R; Kawaguchi, Kosuke; Kharidehal, Durga; Khramtsov, Andrey I; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L; Korski, Konstanty; Kovács, Anikó; Laenkholm, Anne-Vibeke; Lang-Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K; Lerousseau, Marvin; Li, Xiaoxian; Ly, Amy; Madabhushi, Anant; Maley, Sai K; Manur Narasimhamurthy, Vidya; Marks, Douglas K; McDonald, Elizabeth S; Mehrotra, Ravi; Michiels, Stefan; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault-Llorca, Frederique; Perera, Rashindrie D; Pinard, Christopher J; Pinto-Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rahman, Arman; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T; Reis-Filho, Jorge S; Ribeiro, Joana M; Rimm, David; Vincent-Salomon, Anne; Salto-Tellez, Manuel; Saltz, Joel; Sayed, Shahin; Siziopikou, Kalliopi P; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A; Sur, Daniel; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E Aubrey; Tramm, Trine; Tran, William T; van der Laak, Jeroen; van Diest, Paul J; Verghese, Gregory E; Viale, Giuseppe; Vieth, Michael; Wahab, Noorul; Walter, Thomas; Waumans, Yannick; Wen, Hannah Y; Yang, Wentao; Yuan, Yinyin; Adams, Sylvia; Bartlett, John Mark Seaverns; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Salgado, Roberto; Specht Stovgaard, Elisabeth (Peer reviewed; Journal article, 2023)

  Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized ...

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