PhD-avhandlinger (TN-IKBM)
Nye registreringer
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Genetic biomarkers of dementia in Parkinson’s disease
(PhD thesis UiS; 815, Doctoral thesis, 2024)Background: Parkinson's disease (PD) is a complex neurodegenerative disorder with heterogeneous clinical presentation and progression. Cognitive decline and dementia in PD (PDD) are common non-motor complications that ... -
Synthesis of Quinone Metabolites by Electrochemical and Chemical Oxidation
(PhD thesis UiS;, Doctoral thesis, 2024)Electrochemical oxidation of polycyclic aromatic phenols (PAPs) has been developed in a microfluidic flow cell to synthesize polycyclic aromatic quinones. This method applies methanol as a nucleophile source while OH directs ... -
From Research to Clinical Diagnostics: Developing and Validating Biomarkers and Artificial Intelligence for Pathology
(PhD thesis UiS;, Doctoral thesis, 2024)In 2021, digital pathology was deployed in the hospitals of the western health region of Norway. Histological tissue specimens previously viewed under the microscope on glass slides, are now being scanned, and whole slide ... -
Model Development and Investigations on Ion Homeostasis
(PhD thesis UiS;, Doctoral thesis, 2023-05)The environment surrounding an organism, a cell and an organelle is constantly changing. To keep organisms functioning there is an everlasting need to regulate and adapt in order to keep the internal environment relatively ... -
Investigation of Lactam- Based Kinetic Hydrate Inhibitors and the Synergetic Effect of Solvents
(PhD thesis UiS;, Doctoral thesis, 2022)Gas hydrate formation in flow lines is of notorious concern for the oil and gas industry, and it only gets bigger because of the never-ending pursuit of oil and gas compels the industry into deeper and colder waters. Gas ... -
An economic and environmental analysis of greenhouse tomato production in Norway using a model-based technique
(PhD thesis UiS;, Doctoral thesis, 2022-12)The growing global population levels and the resulting increasing demands for food has put a lot of pressure on the food production systems and made the agricultural sector highly energy-intensive. The intensification in ... -
Divergent Synthesis of Indolo[3,2- c]quinolines, Neocryptolepines and Related Tetracyclic Ring-Systems Containing Promising Biological Activities
(PhD thesis UiS;, Doctoral thesis, 2022)Malaria is a devastating tropical disease, claiming approximately 627 000 lives in 2020. Due to the appearance of resistance towards artemisinin-based therapies, the discovery of novel treatments are of paramount ... -
Low-temperature anaerobic wastewater treatment by granulated biomass
(PhD thesis UiS;, Doctoral thesis, 2022-05)In this study, long-term operation of up-flow anaerobic sludge blanket (UASB) system treating real municipal wastewater at decreasing temperatures (25, 16, 12, 8.5, 5.5, and 2.5 °C) and variable organic loading rates from ... -
Synthesis and Photodecomposition Studies of Photodegradable Antibiotics and Chitin Synthase Inhibitors
(PhD thesis UiS;, Doctoral thesis, 2022-05)The release of bioactive compounds to the biosphere, such as chitin synthase inhibitors that are causing negative effects in non-target organisms, or antibiotic agents that contribute to increasing antimicrobial resistance, ... -
Better prognostic markers for nonmuscle invasive papillary urothelial carcinomas
(PhD thesis UiS;, Doctoral thesis, 2022-04)Bladder cancer is a common type of cancer, especially among men in developed countries. Most cancers in the urinary bladder are papillary urothelial carcinomas. They are characterized by a high recurrence frequency (up to ... -
3D in vitro cancer models for drug screening: A study of glucose metabolism and drug response in 2D and 3D culture models
(PhD thesis UiS;, Doctoral thesis, 2022-03)Current drug screening protocols use in vitro cancer cell panels grown in 2D to evaluate drug response and select the most promising candidates for further in vivo testing. Most drug candidates fail at this stage, not ... -
Synthesis of Biologically Active Iminosugars and Strategies Towards the Preparation of Chiral Quinoline Derivatives
(PhD thesis UiS;, Doctoral thesis, 2021-12)Design and preparation of novel bioactive compounds for development of new drug leads is a challenging task. Chirality plays a key role in all biological systems, including drug targets, and stereoisomeric compounds often ... -
Metabolic Cancer Therapy Using Graphene Drug Carriers: A study of biguanide drug effects in cellular and zebrafish larvae model systems
(PhD thesis UiS;, Doctoral thesis, 2021-11)Targeting cancer metabolism is an increasingly important strategy in the fight against cancer relapse. Metabolic drugs belonging to the biguanides family have gained attention in cancer treatment due to their ability to ... -
Protein phosphatase 2A as a regulator and mediator of beneficial plant-microbe interactions
(PhD thesis UiS;, Doctoral thesis, 2021-03)Protein phosphatase 2A (PP2A) is involved in the regulation of stress response, growth and hormone signalling during the plant life cycle. A variety of plant growth-promoting rhizobacteria (PGPR) and arbuscular mycorrhiza ... -
Diastereoselectivity in Anomeric O-alkylation Glycosylation
(PhD thesis UiS;, Doctoral thesis, 2021-02)Biosynth AS used anomeric O-alkylation of α-haloacetophenones in their patented total synthesis of anthocyanins from 2006. There were, however, several challenges with stereoselectivity and yields when performing this ... -
Interleukin-1β, heat shock protein 90α, and hypocretin-1 in chronic fatigue
(PhD thesis UiS;505, Doctoral thesis, 2020-09)Background: Fatigue, defined as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion, is a phenomenon many people have experienced in connection with infections such as influenza, Epstein-Barr ... -
Investigation of New Classes of Amide and Non-amide Kinetic Hydrate Inhibitors
(PhD thesis UiS;538, Doctoral thesis, 2020-09)The formation of gas hydrates can cause pipeline blockage during the transportation of gas and oil products, which is one of the main challenges for flow assurance in the petroleum industry. It is uneasy to remove gas ... -
Energy optimization of biological wastewater treatment using rotating belt filters upstream BNR
(Doctoral thesis, 2020-04)Treatment of wastewater to acceptable permit standards requires energy, mostly as electricity. The typical energy demand for various wastewater treatment technologies vary from 0.30 to 1.50 kWh/m3 of treated water. For ... -
A systems biology approach to cellular homeostasis, volume changes and regulation of metabolism
(PhD thesis UiS;509, Doctoral thesis, 2020-04)Cells need to respond to a vast range of different disturbances and changes over small and large time scales. This can be disturbances in the form of molecules used to fight infectious states, changes in growth patterns, ... -
Regioselective Syntheses and Functionalizations of Polycyclic Aromatic Hydrocarbons: Directed Metalation and C─H Activation
(PhD thesis UiS;484, Doctoral thesis, 2019-12)Polycyclic aromatic hydrocarbons (PAHs) are well-known as pollutants and carcinogenic compounds. Lately, considering their opto-electronic and photophysical properties, PAHs are being developed as materials to be used in ...
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