Browsing Vitenskapelige publikasjoner (HV) by Author "Hagland, Hanne Røland"
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Comparing in vitro cytotoxic drug sensitivity in colon and pancreatic cancer using 2D and 3D cell models: Contrasting viability and growth inhibition in clinically relevant dose and repeated drug cycles
Tidwell, Tia; Røsland, Gro Vatne; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne Røland (Peer reviewed; Journal article, 2024)Background In vitro drug screening that is more translatable to the in vivo tumor environment can reduce both time and cost of cancer drug development. Here we address some of the shortcomings in screening and show how ... -
Elevated microsatellite alterations at selected tetranucleotides (EMAST) is not attributed to MSH3 loss in stage I-III colon cancer: An automated, digitalized assessment by immunohistochemistry of whole slides and hot spots
Watson, Martin; Lea, Dordi; Hagland, Hanne Røland; Søreide, Kjetil (Journal article; Peer reviewed, 2019-12)INTRODUCTION: EMAST is a poorly understood form of microsatellite instability (MSI) in colorectal cancer (CRC) for which loss of MSH3 has been proposed as the underlying mechanism, based on experimental studies. We aimed ... -
Patient-derived organoids from pancreatic cancer after pancreatectomy: Feasibility and organoid take rate in treatment-naïve periampullary tumors
Roalsø, Marcus Thomas Thor; Alexeeva, Marina; Oanæs, Celine; Watson, Martin Matthew Christian; Lea, Dordi; Zaharia, Claudia; Hagland, Hanne Røland; Søreide, Kjetil (Peer reviewed; Journal article, 2024)Background/objective Patient-derived organoids (PDOs) have emerged as essential for ex vivo modelling for pancreatic cancer (PDAC) but reports on efficacy and organoid take rate are scarce. This study aimed to assess the ... -
Prevalence of PD‑L1 expression is associated with EMAST, density of peritumoral T‑cells and recurrence‑free survival in operable non‑metastatic colorectal cancer
Watson, Martin Matthew Christian; Lea, Dordi; Gudlaugsson, Einar; Skaland, Ivar; Hagland, Hanne Røland; Søreide, Kjetil (Peer reviewed; Journal article, 2020-08)Introduction Microsatellite instability (MSI) predict response to anti-PD1 immunotherapy in colorectal cancer (CRC). CRCs with MSI have higher infiltration of immune cells related to a better survival. Elevated Microsatellite ...