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dc.contributor.authorBreitve, Monica Haraldseid
dc.contributor.authorChwiszczuk, Luiza
dc.contributor.authorHynninen, Kia Minna
dc.contributor.authorBrønnick, Kolbjørn Selvåg
dc.contributor.authorAuestad, Bjørn Henrik
dc.contributor.authorAarsland, Dag
dc.contributor.authorRongve, Arvid
dc.identifier.citationBreitve, M.H. et al. (2018) A Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer`s Disease. Frontiers in Neurology, 9:124.nb_NO
dc.description.abstractIntroduction: There are relatively few longitudinal studies on the differences in cognitive decline between Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), and the majority of existing studies have suboptimal designs. Aim: We investigated the differences in cognitive decline in AD compared to DLB over 4 years and cognitive domain predictors of progression. Methods: In a longitudinal study, 266 patients with first-time diagnosis of mild dementia were included and followed annually. The patients were tested annually with neuropsychological tests and screening instruments [MMSE (Mini-Mental Status Examination), Clinical Dementia Rating (CDR), the second edition of California Verbal Learning Test (CVLT-II), Trail Making Test A & B (TMT A & B), Stroop test, Controlled Oral Word Associations Test (COWAT) animal naming, Boston Naming Test, Visual Object and Space Perception Battery (VOSP) Cubes and Silhouettes]. Longitudinal analyses were performed with linear mixed effects (LME) models and Cox regression. Both specific neuropsychological tests and cognitive domains were analyzed. Results: This study sample comprised 119 AD and 67 DLB patients. In TMT A, the DLB patients had a faster decline over 4 years than patients with AD (p = 0.013). No other longitudinal differences in specific neuropsychological tests were found. Higher executive domain scores at baseline were associated with a longer time to reach severe dementia (CDR = 3) or death for the total sample (p = 0.032). High or low visuospatial function at baseline was not found to be associated with cognitive decline (MMSE) or progression of dementia severity (CDR) over time. Conclusion: Over 4 years, patients with DLB had a faster decline in TMT A than patients with AD, but this should be interpreted cautiously. Beyond this, there was little support for faster decline in DLB patients neuropsychologically than in AD patients.nb_NO
dc.publisherFrontiers Media S.A.nb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectdemens med Lewy-legemernb_NO
dc.subjectcognitive declinenb_NO
dc.titleA Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer`s Diseasenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holderCopyright © 2018 Breitve, Chwiszczuk, Brønnick, Hynninen, Auestad, Aarsland and Rongve.nb_NO
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752nb_NO
dc.source.journalFrontiers in Neurologynb_NO
cristin.unitnameDet helsevitenskapelige fakultet
cristin.unitnameInstitutt for matematikk og naturvitenskap

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal