The Effects of Metformin on the Metabolism of Colorectal Cancer Cell Lines SW948 and SW1116
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Metformin is an anti-diabetes drug with cancer preventative capabilities, which is widely studied to help develop treatment to aid future colorectal cancer prevention and recovery. This studies aims were to assess the phenotypes of colorectal cancer cell lines SW948 and SW1116, including detailed analysis of the metabolic shift achieved by the cells to continue growth when stress is applied, via varied metformin concentrations and glucose concentration adjustments. An alternative focus was to locate and achieve quantitative data on how metformin influences expression of organic cation transporter1, which is responsible for transporting metformin into the cell. The results proposed that the effects of metformin on colorectal cancer cells are influenced by cell line and glucose concentrations. When using metformin as a therapeutic agent, taking into consideration the metabolic phenotype of the cancer cell and glucose concentrations to ensure a more unique course of treatment.
Master's thesis in Biological Chemistry