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dc.contributor.authorJoa, Inge
dc.contributor.authorKroken, Rune Andreas
dc.contributor.authorJohnsen, Erik
dc.contributor.authorRettenbacher, Maria
dc.contributor.authorFathian, Farivar
dc.contributor.authorLøberg, Else-Marie
dc.identifier.citationAnda-Ågotnes, L.G., Brønnick, K.K., Johannessen, J.O. et al. (2019) Frontiers in Psychiatry, 10, 1-11.nb_NO
dc.description.abstractBackground: Cognitive impairment is not only a core aspect of schizophrenia but also commonly observed in help-seeking youth at ultra high risk for psychosis (UHR), with potential implications for prognosis and individualized treatment. However, there is no consensus on the cognitive profile in the UHR state, partly due to lack of valid comparisons of performance in established schizophrenia and UHR. Objectives: To compare the cognitive functioning and profile of UHR subjects to a sample with schizophrenia, they were split into two groups based on duration of illness. Comparisons were made using coordinated norms based on healthy controls reflecting the younger UHR age spectrum. Methods: Participants for UHR (n = 51) and schizophrenia groups (n = 19 and n = 22) were included from the Prevention of Psychosis and Bergen Psychosis 2 projects. All subjects completed a comprehensive neurocognitive test battery aiming to measure speed of processing, working memory, verbal learning, reasoning, and problem solving, as well as visual problem solving. Cognitive functioning was compared between groups based on coordinated norms using z-scores derived by regression modeling from an age-matched healthy control group (n = 61). Results: UHR subjects showed significantly impaired speed of processing (p < 0.001) working memory (p = 0.042) and verbal learning, reasoning, and problem solving (p = 0.007) as compared to the control group. Visual problem-solving skills appeared unimpaired. UHR subjects significantly outperformed the schizophrenia group with duration of illness >3 years for speed of processing and working memory (both p < 0.001). There were no significant differences in performance between the UHR group and the group with duration of schizophrenia <3 years. Conclusion: Cognitive performance is impaired in UHR subjects as compared to healthy controls and should thus be monitored when a person is deemed at high risk of psychotic illness. Spatial skills, as measured by tests using physical objects, appear less affected than other domains. The pattern of impairment is similar to that of a group with recent onset schizophrenia but is less severe than in a group with duration of illness <3 years.nb_NO
dc.publisherFrontiers Media S.A.nb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectpsykisk helsenb_NO
dc.titleCognitive profile in ultra high risk for psychosis and schizophrenia: A comparison using coordinated normsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holderCopyright © 2019 Anda, Brønnick, Johannessen, Joa, Kroken, Johnsen, Rettenbacher, Fathian and Løberg.nb_NO
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Psychiatry, child psychiatry: 757nb_NO
dc.source.journalFrontiers in Psychiatrynb_NO
dc.relation.projectUniversitetet i Stavanger: IN-11551nb_NO
cristin.unitnameAvdeling for folkehelse

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal