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dc.contributor.authorKleiven, Øyunn
dc.contributor.authorOmland, Torbjørn
dc.contributor.authorSkadberg, Øyvind
dc.contributor.authorMelberg, Tor Harald
dc.contributor.authorBjørkavoll-Bergseth, Magnus
dc.contributor.authorAuestad, Bjørn Henrik
dc.contributor.authorBergseth, Rolf
dc.contributor.authorGreve, Ole Jacob
dc.contributor.authorAakre, Kristin Moberg
dc.contributor.authorØrn, Stein
dc.identifier.citationKleiven, Ø., Omland, T., Skadberg, Ø. et al. (2019) Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation. International Journal of Cardiology, 283, pp. 1-8.nb_NO
dc.description.abstractBackground The underlying mechanisms of the exercise-induced increase in cardiac troponins (cTn) are poorly understood. The aim of this study was to identify independent determinants of exercise-induced cTn increase in a large cohort of healthy recreational athletes. Methods A total of 1002 recreational cyclists without known cardiovascular disease or medication, participating in a 91-km mountain bike race were included. Median age was 47 years and 78% were males. Blood samples were obtained 24 h prior to, and 3 and 24 h after the race. Results Cardiac TnI concentrations increased markedly from baseline [1.9 (1.6–3.0) ng/L] to 3 h after the race [52.1 (32.4–91.8) ng/L], declining at 24 h after the race [9.9 (6.0–20.0) ng/L]. Similarly, cTnT increased from baseline [3.0 (3.0–4.2) ng/L] to 3 h after the race [35.6 (24.4–54.4) ng/L], followed by a decline at 24 h after the race [10.0 (6.9–15.6) ng/L]. The 99th percentile was exceeded at 3 h after the race in 84% (n = 842) of subjects using the cTnI assay and in 92% (n = 925) of study subjects using the cTnT assay. Shorter race duration and higher systolic blood pressure (SBP) at baseline were highly significant (p < 0.001) independent predictors of exercise-induced cTn increase both in bivariate and multivariable analysis. The age, gender, body mass index, training experience and cardiovascular risk of participants were found to be less consistent predictors. Conclusion Systolic blood pressure and race duration were consistent predictors of the exercise-induced cTn increase. These variables likely reflect important mechanisms involved in the exercise-induced cTn elevation.nb_NO
dc.publisherElsevier Ltd.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleRace duration and blood pressure are major predictors of exercise-induced cardiac troponin elevationnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holder© 2019 Elsevier B.V. All rights reserved.nb_NO
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771nb_NO
dc.source.journalInternational Journal of Cardiologynb_NO
cristin.unitnameInstitutt for matematikk og fysikk
cristin.unitnameInstitutt for data- og elektroteknologi

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal