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1,4-Dideoxy-1,4-imino‑D‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitors

dc.contributor.authorHaarr, Marianne Bore
dc.contributor.authorLopez, Oscar
dc.contributor.authorPejov, Ljupcho
dc.contributor.authorFernandez-Bolanos, Jose G.
dc.contributor.authorLindback, Emil
dc.contributor.authorSydnes, Magne Olav
dc.date.accessioned2020-08-07T10:15:30Z
dc.date.available2020-08-07T10:15:30Z
dc.date.created2020-07-28T16:41:17Z
dc.date.issued2020-07
dc.identifier.citationHaarr, M.B., Lopez, O., Pejov, L. et al. (2020) 1,4-Dideoxy-1,4-imino‑D‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitors. ACS Omega. 2020, 5(29), 18507-18514.en_US
dc.identifier.issn2470-1343
dc.identifier.urihttps://hdl.handle.net/11250/2671187
dc.description.abstractThe synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (Ki values ranging from 0.23 to 1.4 μM).en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectkjemien_US
dc.title1,4-Dideoxy-1,4-imino‑D‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitorsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440en_US
dc.source.pagenumber18507-18514en_US
dc.source.volume5en_US
dc.source.journalACS Omegaen_US
dc.source.issue29en_US
dc.identifier.doi10.1021/acsomega.0c02466
dc.identifier.cristin1820773
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.fulltextoriginal
cristin.qualitycode1


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