dc.contributor.author | Evangelista, Tereza Cristina Santos | |
dc.contributor.author | Lopez, Oscar | |
dc.contributor.author | Ferreira, Sabrina Baptista | |
dc.contributor.author | Fernandez-Bolanos, Jose G. | |
dc.contributor.author | Sydnes, Magne Olav | |
dc.contributor.author | Lindback, Emil | |
dc.date.accessioned | 2021-09-16T13:48:59Z | |
dc.date.available | 2021-09-16T13:48:59Z | |
dc.date.created | 2021-07-23T09:28:58Z | |
dc.date.issued | 2021-07 | |
dc.identifier.citation | Santos Evangelista, T.C., Lopez, O., Baptista Ferreira, S. et al. (2021) Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry, 36(1), pp. 1659-1664. | en_US |
dc.identifier.issn | 1475-6366 | |
dc.identifier.uri | https://hdl.handle.net/11250/2778674 | |
dc.description.abstract | The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Two of the tacrine clusters displayed a small but significant multivalent inhibition potency in which the binding affinity of each of the tacrine binding units increased up to 3.2 times when they are connected to the central scaffold. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Informa UK Ltd. (Taylor & Francis) | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | Acetylcholinesterase | en_US |
dc.subject | tacrine | en_US |
dc.subject | multivalent inhibition potency | en_US |
dc.subject | multivalent interactions | en_US |
dc.title | Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2021 The Author(s) | en_US |
dc.subject.nsi | VDP::Matematikk og Naturvitenskap: 400::Kjemi: 440 | en_US |
dc.source.pagenumber | 1659-1664 | en_US |
dc.source.volume | 36 | en_US |
dc.source.journal | Journal of Enzyme Inhibition and Medicinal Chemistry | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | 10.1080/14756366.2021.1954917 | |
dc.identifier.cristin | 1922460 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |