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dc.contributor.authorNiemi, Mari E.K.
dc.contributor.authorKarjalainen, Juha
dc.contributor.authorLiao, Rachel G.
dc.contributor.authorNeale, Benjamin M.
dc.contributor.authorDaly, Mark
dc.contributor.authorGanna, Andrea
dc.contributor.authorPathak, Gita A.
dc.contributor.authorAndrews, Shea J.
dc.contributor.authorKanai, Masahiro
dc.contributor.authorVeerapen, Kumar
dc.contributor.authorFernandez-Cadenas, Israel
dc.contributor.authorSchulte, Eva C.
dc.contributor.authorStriano, Pasquale
dc.contributor.authorAfset, Jan Egil
dc.contributor.authorSolligård, Erik
dc.contributor.authorDamås, Jan Kristian
dc.contributor.authorRisnes, Kari
dc.contributor.authorBettini, Laura Rachele
dc.contributor.authorGustad, Lise Tuset
dc.contributor.authorHolter, Jan Cato
dc.contributor.authorHov, Johannes Espolin Roksund
dc.contributor.authorKarlsen, Tom Hemming
dc.contributor.authorFolseraas, Trine
dc.contributor.authorHolten, Aleksander Rygh
dc.contributor.authorDyrhol-Riise, Anne Ma
dc.contributor.authorTonby, Kristian
dc.contributor.authorLind, Andreas
dc.contributor.authorMüller, Fredrik
dc.contributor.authorDudman, Susanne Gjeruldsen
dc.contributor.authorGrimsrud, Marit Mæhle
dc.contributor.authorVadla, May Sissel
dc.contributor.authorMyhre, Ronny
dc.contributor.authorKildal, Anders Benjamin
dc.contributor.authorHoff, Dag Arne Lihaug
dc.contributor.authorMuller, Karl Erik
dc.contributor.authorHeggelund, Lars
dc.contributor.authorBergan, Jonas
dc.contributor.authorSkogen, Vegard
dc.identifier.citationCOVID-19 Host Genetics Initiative. (2021) Mapping the human genetic architecture of COVID-19. Nature, 600, 472–477en_US
dc.description.abstractThe genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.en_US
dc.publisherSpringer Nature Switzerland AGen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleMapping the human genetic architecture of COVID-19en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© The Author(s) 2021en_US
dc.subject.nsiVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal