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dc.contributor.authorBorda, Miguel Germán
dc.contributor.authorJaramillo-Jiménez, Alberto
dc.contributor.authorMelvær, Giil Lasse
dc.contributor.authorTovar-Rios, Diego Alejandro
dc.contributor.authorSønnesyn, Hogne
dc.contributor.authorAarsland, Dag
dc.identifier.citationBorda, M.G., Jaramillo-Jimenez, A. Melvær, G.I., Tovar-Rios, D.A., Sønnesyn, H. & Aarsland, D. (2022) Body mass index trajectories and associations with cognitive decline in people with Lewy body dementia and Alzheimer's disease. Health Science Reports, 5 (3).en_US
dc.description.abstractBackground and Aims In older adults with dementia, low body mass index (BMI) is associated with higher mortality and other adverse health outcomes. BMI or nutritional status trajectories from diagnosis have not yet been well described in dementia, especially in people with Lewy body dementia (LBD); a group that has a poorer prognosis. With this study, we aimed to evaluate the BMI trajectory in people diagnosed with mild LBD and Alzheimer's disease (AD). Methods The Dementia Study of Western Norway is a cohort study with annual assessments. Five-year measurements of BMI from 196 patients (LBD = 85 and AD = 111) diagnosed with mild dementia were analyzed using adjusted linear mixed-effects models. Results There were no differences between LBD and AD in baseline BMI, age, or mini-mental status examination (MMSE). During the follow-up, we observed a significant decrease in BMI in the LBD group across the study period (estimation [Est.]: −0.63, SE: 0.14; p < 0.001). By contrast, there was no significant change in BMI trajectory associated with AD diagnosis (Est.: 0.05, SE: 0.15; p = 0.730). Further, the introduction of an interaction term between diagnosis and time in the study showed that this difference (BMI trajectories) was significant (Est.: −0.63, SE: 0.14; p < 0.001). In addition, there was a significant interaction between MMSE total score and the follow-up time; the lower the MMSE, the lower the BMI (Est.: 0.01, SE: 0.01; p = 0.044). Conclusion In LBD, BMI significantly decreased with disease progression. In addition, low cognitive performance was associated with a reduction in BMI. These results highlight the importance of BMI evaluation in people with dementia, particularly patients diagnosed with LBD, and suggest that patients with LBD could be targeted for dietary intervention to maintain body weight.en_US
dc.publisherWiley Periodicals LLC.en_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.subjectdemens med Lewy-legemeren_US
dc.subjectkognitiv funksjonen_US
dc.titleBody mass index trajectories and associations with cognitive decline in people with Lewy body dementia and Alzheimer's diseaseen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2022 The Authorsen_US
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752en_US
dc.source.journalHealth Science Reportsen_US

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal