dc.contributor.author | Aase, Ingvild | |
dc.contributor.author | Langeveld, Johannes Hendrik | |
dc.contributor.author | Johannessen, Jan Olav | |
dc.contributor.author | Joa, Inge | |
dc.contributor.author | Dalen, Ingvild | |
dc.contributor.author | Hegelstad, Wenche | |
dc.date.accessioned | 2022-12-14T19:09:01Z | |
dc.date.available | 2022-12-14T19:09:01Z | |
dc.date.created | 2021-12-21T16:08:17Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Aase, I., Langeveld, J.H., Johannessen, J.O., Joa, I., Dalen, I., Hegelstad, W. (2021) Schizophrenia Research: Cognition, 26, 100210. | |
dc.identifier.issn | 2215-0013 | |
dc.identifier.uri | https://hdl.handle.net/11250/3037800 | |
dc.description.abstract | Background
Clinical High Risk (CHS) for psychosis is a state in which positive symptoms are predominant but do not reach a level of severity that fulfils the criteria for a psychotic episode. The aim of this study has been to investigate whether cognition in subjects with newly detected CHR affects the longitudinal development of positive symptoms.
Methods
Fifty-three CHR individuals fulfilling the criteria for attenuated positive syndrome in the Structural Interview for Prodromal Syndromes (SIPS) were included. At inclusion, all participants completed a neurocognitive battery consisting of tests measuring attention, verbal memory, verbal fluency, executive functions and general intelligence. Cognitive domain z-scores were defined by contrasting with observed scores of a group of matched healthy controls (n = 40). Associations between cognitive performance at inclusion and longitudinal measures of positive symptoms were assessed by using generalised linear models including non-linear effects of time. All regression models were adjusted for age and gender.
Results
Overall, SIPS positive symptoms declined over the time period, with a steeper decline during the first six months. Deficits in executive functions were assossiated witn a higher load of positive symptoms at baseline (p=0.006), but also to a faster improvement (p=0.030), wheras those with poor verbal fluency improved more slowly (p=0.018).
Conclusion
To our knowledge, this is the first study that follows CHR subjects by means of frequent clinical interviews over a sustained period of time. The study provides evidence of an association between executive functions, including verbal fluency, with the evolvement of positive symptoms. | |
dc.language.iso | eng | |
dc.title | Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis | |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | |
dc.source.pagenumber | 7 | |
dc.source.volume | 26 | |
dc.source.journal | Schizophrenia Research: Cognition | |
dc.identifier.doi | 10.1016/j.scog.2021.100210 | |
dc.identifier.cristin | 1971172 | |
dc.relation.project | Helse Vest RHF: 911881 | |
dc.relation.project | Helse Vest RHF: 13968 | |
dc.relation.project | Norges forskningsråd: 913184 | |
dc.relation.project | Helse Vest RHF: 911508 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |