dc.contributor.author | Vanhatalo, Anni | |
dc.contributor.author | L’Heureux, Johanna E. | |
dc.contributor.author | Kelly, James | |
dc.contributor.author | Blackwell, Jamie | |
dc.contributor.author | Wylie, Lee | |
dc.contributor.author | Fulford, Jonathan | |
dc.contributor.author | Winyard, Paul | |
dc.contributor.author | Williams, David | |
dc.contributor.author | van der Giezen, Mark | |
dc.contributor.author | Jones, Andrew | |
dc.date.accessioned | 2023-02-15T12:47:02Z | |
dc.date.available | 2023-02-15T12:47:02Z | |
dc.date.created | 2021-04-12T10:18:16Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Vanhatalo, A., L'Heureux, J. E., Kelly, J., Blackwell, J. R., Wylie, L. J., Fulford, J., ... & Jones, A. M. (2021). Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions. Redox Biology, 41, 101933. | en_US |
dc.identifier.issn | 2213-2317 | |
dc.identifier.uri | https://hdl.handle.net/11250/3051132 | |
dc.description.abstract | Many oral bacteria reduce inorganic nitrate, a natural part of a vegetable-rich diet, into nitrite that acts as a precursor to nitric oxide, a regulator of vascular tone and neurotransmission. Aging is hallmarked by reduced nitric oxide production with associated detriments to cardiovascular and cognitive function. This study applied a systems-level bacterial co-occurrence network analysis across 10-day dietary nitrate and placebo interventions to test the stability of relationships between physiological and cognitive traits and clusters of co-occurring oral bacteria in older people. Relative abundances of Proteobacteria increased, while Bacteroidetes, Firmicutes and Fusobacteria decreased after nitrate supplementation. Two distinct microbiome modules of co-occurring bacteria, that were sensitive to nitrate supplementation, showed stable relationships with cardiovascular (Rothia-Streptococcus) and cognitive (Neisseria-Haemophilus) indices of health across both dietary conditions. A microbiome module (Prevotella-Veillonella) that has been associated with pro-inflammatory metabolism was diminished after nitrate supplementation, including a decrease in relative abundance of pathogenic Clostridium difficile. These nitrate-sensitive oral microbiome modules are proposed as potential pre- and probiotic targets to ameliorate age-induced impairments in cardiovascular and cognitive health. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | The authors | en_US |
dc.subject.nsi | VDP::Medisinske Fag: 700 | en_US |
dc.source.volume | 41 | en_US |
dc.source.journal | Redox Biology | en_US |
dc.identifier.doi | 10.1016/j.redox.2021.101933 | |
dc.identifier.cristin | 1903471 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |