dc.contributor.author | Nieder, Carsten | |
dc.contributor.author | Haukland, Ellinor Christin | |
dc.contributor.author | Mannsåker, Bård | |
dc.date.accessioned | 2023-03-16T11:32:27Z | |
dc.date.available | 2023-03-16T11:32:27Z | |
dc.date.created | 2023-01-16T13:14:24Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Nieder, C., Haukland, E. C., & Mannsåker, B. (2022). Shortened Palliative Radiotherapy Results in a Lower Rate of Treatment During the Last Month of Life. Cureus, 14(1). | en_US |
dc.identifier.issn | 1748-717X | |
dc.identifier.uri | https://hdl.handle.net/11250/3058731 | |
dc.description.abstract | Introduction
Palliative radiotherapy (PRT) during the last month of life (PRT30) should be avoided because relevant clinical benefits are unlikely to occur. While traditional short-course fractionation regimens are suitable for most patients, a minority may derive gains from higher doses of PRT. Compared to older regimens such as 13 fractions of 3 Gy, more hypofractionated, non-ablative concepts with reduced overall treatment time are not well studied.
Methods
Retrospective analysis (2017-2020) of 107 patients treated to metastatic lesions (one or two target volumes per patient) with traditional >2 weeks regimens or newer ≤2 weeks regimens, e.g. seven fractions of 5 Gy or five fractions of 6 Gy.
Results
Failure to complete radiotherapy was registered in 8% of patients (traditional fractionation) and 1%, respectively (p=0.12). Moderate rates of PRT30 were observed (11% and 6%, respectively, p=0.44). PRT30 was more likely in patients irradiated for brain or lymph node metastases. Utilization of newer ≤2 weeks regimens was highest in 2020, presumably as a result of the coronavirus disease 2019 (COVID-19) pandemic.
Conclusion
The implementation of newer fractionation regimens for selected patients has resulted in acceptable rates of non-completion and PRT30. Optimal selection criteria remain to be determined. Established, guideline-endorsed short-course regimens such as five fractions of 4 Gy and 8-Gy single fractions continue to represent important PRT approaches. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Cureus | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Shortened Palliative Radiotherapy Results in a Lower Rate of Treatment During the Last Month of Life | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | The authors | en_US |
dc.subject.nsi | VDP::Medisinske Fag: 700 | en_US |
dc.source.volume | 14(1) | en_US |
dc.source.journal | Radiation Oncology | en_US |
dc.identifier.doi | 10.7759/cureus.21617 | |
dc.identifier.cristin | 2107646 | |
dc.relation.project | SHARE - Centre for Resilience in Healthcare: 5091 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |