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dc.contributor.authorAaen, Jørn Ståle
dc.contributor.authorBanitalebi, Hasan
dc.contributor.authorAustevoll, Ivar Magne
dc.contributor.authorHellum, Christian
dc.contributor.authorStorheim, Kjersti
dc.contributor.authorMyklebust, Tor Åge
dc.contributor.authorAnvar, Masoud D
dc.contributor.authorWeber, Clemens
dc.contributor.authorSolberg, Tore
dc.contributor.authorGrundnes, Oliver
dc.contributor.authorBrisby, Helena
dc.contributor.authorIndrekvam, Kari
dc.contributor.authorHermansen, Erland
dc.identifier.citationAaen, J., Banitalebi, H., Austevoll, I. M., Hellum, C., Storheim, K., Myklebust, T. Å., ... & Hermansen, E. (2022). The association between preoperative MRI findings and clinical improvement in patients included in the NORDSTEN spinal stenosis trial. European Spine Journal, 31(10), 2777-2785.en_US
dc.description.abstractPurpose To investigate potential associations between preoperative MRI findings and patient reported outcome measures (PROMs) after surgery for lumbar spinal stenosis (LSS). Methods The NORDSTEN trial included 437 patients. We investigated the association between preoperative MRI findings such as morphological grade of stenosis (Schizas grade), quantitative grade of stenosis (dural sac cross-sectional area), disc degeneration (Pfirrmann score), facet joint tropism and fatty infiltration of the multifidus muscle, and improvement in patient reported outcome measures (PROMs) 2 years after surgery. We dichotomized each radiological parameter into a moderate or severe category. PROMs i.e., Oswestry Disability Index (ODI), Zurich Claudication Questionnaire (ZCQ) and Numeric rating scale (NRS) for back and leg pain were collected before surgery and at 2 year follow-up. In the primary analysis, we investigated the association between MRI findings and ODI score (dichotomized to ≥ 30% improvement or not). In the secondary analysis, we investigated the association between MRI findings and the mean improvement on the ODI-, ZCQ- and NRS scores. We used multivariable regression models adjusted for patients’ gender, age, smoking status and BMI. Results The primary analysis showed that severe disc degeneration (Pfirrmann score 4–5) was significantly associated with less chance of achieving a 30% improvement on the ODI score (OR 0.54, 95% CI 0.34, 0.88). In the secondary analysis, we detected no clinical relevant associations. Conclusion Severe disc degeneration preoperatively suggest lesser chance of achieving 30% improvement in ODI score after surgery for LSS. Other preoperative MRI findings were not associated with patient reported outcome.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleThe association between preoperative MRI findings and clinical improvement in patients included in the NORDSTEN spinal stenosis trialen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holderthe authorsen_US
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.source.journalEuropean spine journalen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal