Photodegradable Antimicrobial Agents: Towards Structure Optimization
Alves Souto de Aquino, Gabriel; Nguyen van Sang, Liza Maëva; Valery, Romane; Lanave, Maelys; Estopiñá-Durán, Susana; Håheim, Katja Stangeland; Baptista Ferreira, Sabrina; Sydnes, Magne Olav
Peer reviewed, Journal article
Published version
Permanent lenke
https://hdl.handle.net/11250/3105615Utgivelsesdato
2023Metadata
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Originalversjon
de Aquino, G. A. S., Van Sang, L. N., Valery, R., Lanave, M., Estopiñá-Durán, S., Håheim, K. S., ... & Sydnes, M. O. (2023). Photodegradable antimicrobial agents: towards structure optimization. RSC advances, 13(42), 29729-29734. 10.1039/d3ra05554jSammendrag
Antibiotic resistance continues to be an ominous threat facing human health globally and urgent action is required to limit the loss of human life. The pollution of antibiotics into the environment is one of the drivers behind the crisis. With this in mind, we have developed novel photodecomposable antimicrobial agents based on an ethanolamine scaffold, which upon photoirradiation decomposes into two major inactive fragments. Herein we describe our further work on the synthesis of novel ethanolamines with a particular focus on structure activity relationship, resulting in four new active compounds which photodecomposed into inactive fragments.