MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
Inguanzo, Anna; Poulakis, Konstantinos; Mohanty, Rosaleena; Schwarz, Christopher G.; Przybelski, Scott A.; Diaz-Galvan, Patricia; Lowe, Val J.; Boeve, Bradley F.; Lemstra, Afina W.; van de Beek, Marleen; van der Flier, Wiesje; Barkhof, Frederik; Blanc, Frederic; Loureiro de Sousa, Paulo; Philippi, Nathalie; Cretin, Benjamin; Demuynck, Catherine; Nedelska, Zuzana; Hort, Jakub; Segura, Barbara; Junque, Carme; Oppedal, Ketil; Aarsland, Dag; Westman, Eric; Kantarci, Kejal; Ferreira, Daniel
Peer reviewed, Journal article
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2023Metadata
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Inguanzo, A., Poulakis, K., Mohanty, R., Schwarz, C. G., Przybelski, S. A., Diaz-Galvan, P., ... & Ferreira, D. (2023). MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies. npj Parkinson's Disease, 9(1), 5. 10.1038/s41531-023-00448-6Abstract
Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes. We included 165 DLB from the Mayo Clinic and 3 centers from the European DLB consortium and performed a hierarchical cluster analysis to identify subtypes based on gray matter (GM) volumes. To characterize the subtypes, we used demographic and clinical data, as well as β-amyloid, tau, and cerebrovascular biomarkers at baseline, and cognitive decline over three years. We identified 3 subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline (n = 49, 30%); a subtype with low GM volumes in fronto-occipital regions (n = 76, 46%); and a subtype of younger patients with the highest cortical GM volumes, proportionally lower GM volumes in basal ganglia and the highest frequency of cognitive fluctuations (n = 40, 24%). This study shows the existence of MRI subtypes in DLB, which may have implications for clinical workout, research, and therapeutic decisions.