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Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer

dc.contributor.authorPage, David B
dc.contributor.authorBroeckx, Glenn
dc.contributor.authorJahangir, Chowdhury Arif
dc.contributor.authorVerbandt, Sara
dc.contributor.authorGupta, Rajarsi R
dc.contributor.authorThagaard, Jeppe
dc.contributor.authorKhiroya, Reena
dc.contributor.authorKos, Zuzana
dc.contributor.authorAbduljabbar, Khalid
dc.contributor.authorAcosta Haab, Gabriela
dc.contributor.authorAcs, Balazs
dc.contributor.authorAkturk, Guray
dc.contributor.authorAlmeida, Jonas S
dc.contributor.authorAlvarado-Cabrero, Isabel
dc.contributor.authorAzmoudeh-Ardalan, Farid
dc.contributor.authorBadve, Sunil
dc.contributor.authorBaharun, Nurkhairul Bariyah
dc.contributor.authorBellolio, Enrique R
dc.contributor.authorBheemaraju, Vydehi
dc.contributor.authorBlenman, Kim RM
dc.contributor.authorBotinelly Mendonça Fujimoto, Luciana
dc.contributor.authorBouchmaa, Najat
dc.contributor.authorBurgues, Octavio
dc.contributor.authorCheang, Maggie Chon U
dc.contributor.authorCiompi, Francesco
dc.contributor.authorCooper, Lee AD
dc.contributor.authorCoosemans, An
dc.contributor.authorCorredor, Germán
dc.contributor.authorDantas Portela, Flavio Luis
dc.contributor.authorDeman, Frederik
dc.contributor.authorDemaria, Sandra
dc.contributor.authorDudgeon, Sarah N
dc.contributor.authorElghazawy, Mahmoud
dc.contributor.authorEly, Scott
dc.contributor.authorFernandez-Martín, Claudio
dc.contributor.authorFineberg, Susan
dc.contributor.authorFox, Stephen B
dc.contributor.authorGallagher, William M
dc.contributor.authorGiltnane, Jennifer M
dc.contributor.authorGnjatic, Sacha
dc.contributor.authorGonzalez-Ericsson, Paula I
dc.contributor.authorGrigoriadis, Anita
dc.contributor.authorHalama, Niels
dc.contributor.authorHanna, Matthew G
dc.contributor.authorHarbhajanka, Aparna
dc.contributor.authorHardas, Alexandros
dc.contributor.authorHart, Steven N
dc.contributor.authorHartman, Johan
dc.contributor.authorHewitt, Stephen
dc.contributor.authorHida, Akira I
dc.contributor.authorHorlings, Hugo M
dc.contributor.authorHusain, Zaheed
dc.contributor.authorHytopoulos, Evangelos
dc.contributor.authorIrshad, Sheeba
dc.contributor.authorJanssen, Emiel
dc.contributor.authorKahila, Mohamed
dc.contributor.authorKataoka, Tatsuki R
dc.contributor.authorKawaguchi, Kosuke
dc.contributor.authorKharidehal, Durga
dc.contributor.authorKhramtsov, Andrey I
dc.contributor.authorKiraz, Umay
dc.contributor.authorKirtani, Pawan
dc.contributor.authorKodach, Liudmila L
dc.contributor.authorKorski, Konstanty
dc.contributor.authorKovács, Anikó
dc.contributor.authorLaenkholm, Anne-Vibeke
dc.contributor.authorLang-Schwarz, Corinna
dc.contributor.authorLarsimont, Denis
dc.contributor.authorLennerz, Jochen K
dc.contributor.authorLerousseau, Marvin
dc.contributor.authorLi, Xiaoxian
dc.contributor.authorLy, Amy
dc.contributor.authorMadabhushi, Anant
dc.contributor.authorMaley, Sai K
dc.contributor.authorManur Narasimhamurthy, Vidya
dc.contributor.authorMarks, Douglas K
dc.contributor.authorMcDonald, Elizabeth S
dc.contributor.authorMehrotra, Ravi
dc.contributor.authorMichiels, Stefan
dc.contributor.authorMinhas, Fayyaz ul Amir Afsar
dc.contributor.authorMittal, Shachi
dc.contributor.authorMoore, David A
dc.contributor.authorMushtaq, Shamim
dc.contributor.authorNighat, Hussain
dc.contributor.authorPapathomas, Thomas
dc.contributor.authorPenault-Llorca, Frederique
dc.contributor.authorPerera, Rashindrie D
dc.contributor.authorPinard, Christopher J
dc.contributor.authorPinto-Cardenas, Juan Carlos
dc.contributor.authorPruneri, Giancarlo
dc.contributor.authorPusztai, Lajos
dc.contributor.authorRahman, Arman
dc.contributor.authorRajpoot, Nasir Mahmood
dc.contributor.authorRapoport, Bernardo Leon
dc.contributor.authorRau, Tilman T
dc.contributor.authorReis-Filho, Jorge S
dc.contributor.authorRibeiro, Joana M
dc.contributor.authorRimm, David
dc.contributor.authorVincent-Salomon, Anne
dc.contributor.authorSalto-Tellez, Manuel
dc.contributor.authorSaltz, Joel
dc.contributor.authorSayed, Shahin
dc.contributor.authorSiziopikou, Kalliopi P
dc.contributor.authorSotiriou, Christos
dc.contributor.authorStenzinger, Albrecht
dc.contributor.authorSughayer, Maher A
dc.contributor.authorSur, Daniel
dc.contributor.authorSymmans, Fraser
dc.contributor.authorTanaka, Sunao
dc.contributor.authorTaxter, Timothy
dc.contributor.authorTejpar, Sabine
dc.contributor.authorTeuwen, Jonas
dc.contributor.authorThompson, E Aubrey
dc.contributor.authorTramm, Trine
dc.contributor.authorTran, William T
dc.contributor.authorvan der Laak, Jeroen
dc.contributor.authorvan Diest, Paul J
dc.contributor.authorVerghese, Gregory E
dc.contributor.authorViale, Giuseppe
dc.contributor.authorVieth, Michael
dc.contributor.authorWahab, Noorul
dc.contributor.authorWalter, Thomas
dc.contributor.authorWaumans, Yannick
dc.contributor.authorWen, Hannah Y
dc.contributor.authorYang, Wentao
dc.contributor.authorYuan, Yinyin
dc.contributor.authorAdams, Sylvia
dc.contributor.authorBartlett, John Mark Seaverns
dc.contributor.authorLoibl, Sibylle
dc.contributor.authorDenkert, Carsten
dc.contributor.authorSavas, Peter
dc.contributor.authorLoi, Sherene
dc.contributor.authorSalgado, Roberto
dc.contributor.authorSpecht Stovgaard, Elisabeth
dc.date.accessioned2024-02-20T12:10:42Z
dc.date.available2024-02-20T12:10:42Z
dc.date.created2023-09-27T10:28:37Z
dc.date.issued2023
dc.identifier.citationPage, D. B., Broeckx, G., Jahangir, C. A., Verbandt, S., Gupta, R. R., Thagaard, J., ... & Specht Stovgaard, E. (2023). Spatial analyses of immune cell infiltration in cancer: current methods and future directions: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer. The Journal of pathology, 260(5), 514-532.en_US
dc.identifier.issn0022-3417
dc.identifier.urihttps://hdl.handle.net/11250/3118664
dc.description.abstractModern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.titleSpatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Canceren_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holderThe owners/authorsen_US
dc.subject.nsiVDP::Medisinske Fag: 700en_US
dc.source.pagenumber514-532en_US
dc.source.volume260en_US
dc.source.journalJournal of Pathologyen_US
dc.source.issue5en_US
dc.identifier.doi10.1002/path.6165
dc.identifier.cristin2179285
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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