dc.contributor.author | Tufekcioglu, Zeynep | |
dc.contributor.author | Lange, Johannes | |
dc.contributor.author | Pedersen, Kenn Freddy | |
dc.contributor.author | Tysnes, Ole-Bjørn | |
dc.contributor.author | Alves, Guido Werner | |
dc.contributor.author | Emre, Murat | |
dc.date.accessioned | 2024-04-24T11:39:05Z | |
dc.date.available | 2024-04-24T11:39:05Z | |
dc.date.created | 2023-12-20T09:13:57Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Tufekcioglu, Z., Lange, J., Pedersen, K. F., Tysnes, O. B., Alves, G., & Emre, M. (2023). Cognitive Profile in Parkinson’s Disease Dementia Patients with Low versus Normal Cerebrospinal Fluid Amyloid Beta. Dementia and Geriatric Cognitive Disorders Extra, 13(1), 39-47. | en_US |
dc.identifier.issn | 1664-5464 | |
dc.identifier.uri | https://hdl.handle.net/11250/3127936 | |
dc.description.abstract | Introduction: In patients with Parkinson’s disease (PD), low cerebrospinal fluid (CSF) amyloid beta 1-42 (Ab42) at baseline is the most consistent CSF biomarker as a risk factor for developing dementia. Low CSF Ab42 is, however, a typical hallmark of Alzheimer’s disease (AD). Hence, low CSF Ab42 in patients with PD may indicate presence of comorbid AD pathology and may predict a more AD-like cognitive profile when they develop dementia. Our study aimed to investigate if low CSF Ab42 at baseline is associated with a more AD-like cognitive profile in PD patients with dementia. Methods: In a prospectively followed-up, population-based cohort of newly diagnosed PD patients, we compared the cognitive profile of dementia in those with a low CSF Ab42 level at baseline with that of patients who had normal levels at the time when they developed dementia. Four different cognitive domain z-scores (memory, attention, executive, visuospatial) were calculated. Patients were subdivided into three tertiles or categorized dichotomously based on the baseline CSF Ab42 levels as measured by electrochemiluminescence and ELISA. Results: During 10-year follow-up, 37 patients met the inclusion criteria. Memory domain composite z-scores, memory subtest z-scores, and the difference between long-delay free recall versus recognition scores were not significantly different between the groups. Composite z-scores of visuospatial functions significantly differed between the tertiles, which was not significant after Bonferroni correction. In the dichotomous group analysis, z-scores of visuospatial functions significantly differed between the two groups. The other cognitive domain z-scores were not significantly different. Conclusions: In patients with PD dementia, low CSF Ab42 level at baseline is not associated with a specific cognitive profile. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Karger | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Cognitive Profile in Parkinson’s Disease Dementia Patients with Low versus Normal Cerebrospinal Fluid Amyloid Beta | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | The authors | en_US |
dc.subject.nsi | VDP::Medisinske Fag: 700 | en_US |
dc.source.pagenumber | 39-47 | en_US |
dc.source.journal | Dementia and Geriatric Cognitive Disorders Extra | en_US |
dc.identifier.doi | 10.1159/000534552 | |
dc.identifier.cristin | 2216009 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |