dc.contributor.author | Antonsdottir, Inga Margaret | |
dc.contributor.author | Creese, Byron | |
dc.contributor.author | Klei, Lambertus | |
dc.contributor.author | DeMichele-Sweet, Mary Ann A. | |
dc.contributor.author | Weamer, Elise A. | |
dc.contributor.author | Garcia-Gonzalez, Pablo | |
dc.contributor.author | Marquié, Marta | |
dc.contributor.author | Boada, Mercé | |
dc.contributor.author | Alarcón-Martín, Emilio | |
dc.contributor.author | Valero, Sergi | |
dc.contributor.author | Liu, Yushi | |
dc.contributor.author | Hooli, Basavaraj | |
dc.contributor.author | Aarsland, Dag | |
dc.contributor.author | Selbæk, Geir | |
dc.contributor.author | Bergh, Sverre | |
dc.contributor.author | Rongve, Arvid | |
dc.contributor.author | Saltvedt, Ingvild Tina | |
dc.contributor.author | Skjellegrind, Håvard Kjesbu | |
dc.contributor.author | Engdahl, Bo Lars | |
dc.contributor.author | Andreassen, Ole | |
dc.contributor.author | Borroni, Barbara | |
dc.contributor.author | Mecocci, Patrizia | |
dc.contributor.author | Wedatilake, Yehani | |
dc.contributor.author | Mayeux, Richard | |
dc.contributor.author | Foroud, Tatiana M. | |
dc.contributor.author | Ruiz, Agustin | |
dc.contributor.author | Lopez, Oscar L. | |
dc.contributor.author | Kamboh, M. Ilyas | |
dc.contributor.author | Ballard, Clive | |
dc.contributor.author | Devlin, Bernie | |
dc.contributor.author | Lyketsos, Constantine | |
dc.contributor.author | Sweet, Robert A. | |
dc.date.accessioned | 2024-08-30T12:56:32Z | |
dc.date.available | 2024-08-30T12:56:32Z | |
dc.date.created | 2024-05-29T11:21:29Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Antonsdottir, I. M., Creese, B., Klei, L., DeMichele‐Sweet, M. A. A., Weamer, E. A., Garcia‐Gonzalez, P., ... & Sweet, R. A. (2024). Genetic associations with psychosis and affective disturbance in Alzheimer's disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 10(2), e12472. | en_US |
dc.identifier.issn | 1552-5260 | |
dc.identifier.uri | https://hdl.handle.net/11250/3149385 | |
dc.description.abstract | INTRODUCTION
Individuals with Alzheimer's disease (AD) commonly experience neuropsychiatric symptoms of psychosis (AD+P) and/or affective disturbance (depression, anxiety, and/or irritability, AD+A). This study's goal was to identify the genetic architecture of AD+P and AD+A, as well as their genetically correlated phenotypes.
METHODS
Genome-wide association meta-analysis of 9988 AD participants from six source studies with participants characterized for AD+P AD+A, and a joint phenotype (AD+A+P).
RESULTS
AD+P and AD+A were genetically correlated. However, AD+P and AD+A diverged in their genetic correlations with psychiatric phenotypes in individuals without AD. AD+P was negatively genetically correlated with bipolar disorder and positively with depressive symptoms. AD+A was positively correlated with anxiety disorder and more strongly correlated than AD+P with depressive symptoms. AD+P and AD+A+P had significant estimated heritability, whereas AD+A did not. Examination of the loci most strongly associated with the three phenotypes revealed overlapping and unique associations.
DISCUSSION
AD+P, AD+A, and AD+A+P have both shared and divergent genetic associations pointing to the importance of incorporating genetic insights into future treatment development. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley Periodicals LLC on behalf of Alzheimer's Association. | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.subject | Alzheimer | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.title | Genetic associations with psychosis and affective disturbance in Alzheimer's disease | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2024 The Author(s). | en_US |
dc.subject.nsi | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752 | en_US |
dc.source.pagenumber | 11 | en_US |
dc.source.volume | 10 | en_US |
dc.source.journal | Alzheimer's & Dementia | en_US |
dc.source.issue | 2 | en_US |
dc.identifier.doi | 10.1002/trc2.12472 | |
dc.identifier.cristin | 2271712 | |
dc.source.articlenumber | e12472 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |