Browsing Department of Chemistry, Bioscience and Environmental Engineering (TN-IKBM) by Title
Now showing items 101-120 of 498
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Design, synthesis and antitumor evaluation of novel pyrazolopyrimidines and pyrazoloquinazolines
(Journal article; Peer reviewed, 2018-05)A series of N-aryl-7-aryl-pyrazolo[1,5-a]pyrimidines 18a–u and N-aryl-pyrazolo[1,5-a] quinazolines 25a–c were designed and synthesized via the reaction of 5-aminopyrazoles 11a–c with enaminones 12a–g or 19, respectively. ... -
Design, Synthesis, Anticancer Evaluation, Enzymatic Assays, and a Molecular Modeling Study of Novel Pyrazole−Indole Hybrids
(Peer reviewed; Journal article, 2021-04)The molecular hybridization concept has recently emerged as a powerful approach in drug discovery. A series of novel indole derivatives linked to the pyrazole moiety were designed and developed via a molecular hybridization ... -
Destabilization of crude oil sludges by chemical and mechanical treatment
(Master thesis, 2022)The demand for petroleum is still increasing. As a result, various wastes are generated during exploration and production, even though strict rules and regulations are applied to oil and gas industries to optimize waste ... -
Detection and quantification of pharmaceuticals in sediment, seawater, and wastewater treatment plant samples
(Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-07-15)Active pharmaceutical ingredients (APIs) are increasingly occurring in nature. Their presence is posing a concern about antibiotic resistance in bacteria and other effects on the ecosystem, which are not yet fully understood. ... -
Detection of Nrf2 in peripheral blood mononuclear cells: comparison and application of two methods
(Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-11-01)Protein nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates expression of numerous proteins. These proteins protect cells against oxidative stress and reinstate cellular homeostasis. ... -
Determination of bioavailable phosphorus retention in Leikvollbekken constructed wetland by a novel algae bioassay
(Master thesis, 2022)Excessive phosphorus loads from agricultural runoff contribute to freshwater eutrophication, which leads to reduced water quality and changes across all trophic levels. Constructed wetlands, specially designed to retain ... -
Determination of eleven steroid hormones and bioavailable testosterone in human serum using salting-out assisted liquid-liquid extraction with UHPLC-MS/MS
(Master thesis, 2023)Steroid hormones are essential in various biological roles such as the regulation of sexual maturation, fertility, bone and muscle growth, stress-mediated responses, and inflammation, to name a few examples. Impaired ... -
Development of a constitutive and an auto-inducible high-yield expression system for recombinant protein production in the microalga Nannochloropsis oceanica
(Peer reviewed; Journal article, 2020-09)Photoautotrophic microalgae offer a great potential as novel hosts for efficient recombinant protein production. Nannochloropsis oceanica produces an extraordinarily high content of polyunsaturated fatty acids, and its ... -
Development of a portable surface plasmon resonance based genosensor for the detection of obligate hydrocarbon degrading bacteria in the marine environment
(Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-06-01)This study aimed at developing a genosensor that could be implemented in the Environmental Sample Processor (ESP) based on surface plasmon resonance (SPR) to detect obligate hydrocarbonoclastic bacteria (OHCB) that can be ... -
Development of LC-MS/MS method for analysing immunosuppressants in whole blood for the purpose of TDM, with the novel application of SALLE in the sample preparation
(Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-07-06)The laboratory for Medical Biochemistry at Stavanger University Hospital (SUS) needed a new method for analysing tacrolimus, sirolimus, everolimus and cyclosporin A. A method was developed using the analytical principles ... -
Development of Naval Controlling Loops for Primary Sludge Thickening Process at SNJ Wastewater Treatment Plant
(Master thesis, 2021)The solid concentration of primary sludge is increased by thickening process of the wastewater treatment plant (WWTP). At SNJ WWTP, rotary drum thickener is used to thicken primary sludge and expected to obtain 5 ±1 % ... -
Development of new Corrosion Inhibitors
(Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-06-15)Pipelines are an essential part of the oil ang gas industry as they are the main means of transportation. As the offshore technology advances, subsea pipelines are being operated in more demanding environments. In field ... -
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
(Peer reviewed; Journal article, 2021-07)The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters ... -
Diastereoselectivity in Anomeric O-alkylation Glycosylation
(PhD thesis UiS;, Doctoral thesis, 2021-02)Biosynth AS used anomeric O-alkylation of α-haloacetophenones in their patented total synthesis of anthocyanins from 2006. There were, however, several challenges with stereoselectivity and yields when performing this ... -
Differential transcript usage in the Parkinson’s disease brain
(Peer reviewed; Journal article, 2020)Studies of differential gene expression have identified several molecular signatures and pathways associated with Parkinson’s disease (PD). The role of isoform switches and differential transcript usage (DTU) remains, ... -
Directed ortho-Metalation and Anionic ortho-Fries Rearrangement of Polycyclic Aromatic O-Carbamates: Regioselective Synthesis of Substituted Chrysenes
(Peer reviewed; Journal article, 2018-03)A general method for the regioselective synthesis of a series of ortho-substituted chrysenyl N,N-diethyl-O-carbamates by the directed ortho-metalation (DoM) strategy is reported. The starting O-carbamates were prepared ... -
Distinct Clades of Protein Phosphatase 2A Regulatory B’/B56 Subunits Engage in Different Physiological Processes
(Peer reviewed; Journal article, 2023-07)Protein phosphatase 2A (PP2A) is a strongly conserved and major protein phosphatase in all eukaryotes. The canonical PP2A complex consists of a catalytic (C), scaffolding (A), and regulatory (B) subunit. Plants have three ... -
Distinct Gene Expression Profiles of Matched Primary and Metastatic Triple-Negative Breast Cancers
(Peer reviewed; Journal article, 2022)Background: Although triple-negative breast cancer (TNBC) is associated with an increased risk of recurrence and metastasis, the molecular mechanisms underlying metastasis in TNBC remain unknown. To identify transcriptional ... -
Divergent Synthesis of Indolo[3,2- c]quinolines, Neocryptolepines and Related Tetracyclic Ring-Systems Containing Promising Biological Activities
(PhD thesis UiS;, Doctoral thesis, 2022)Malaria is a devastating tropical disease, claiming approximately 627 000 lives in 2020. Due to the appearance of resistance towards artemisinin-based therapies, the discovery of novel treatments are of paramount ... -
DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water
(Peer reviewed; Journal article, 2020)The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by ...