Browsing Department of Chemistry, Bioscience and Environmental Engineering (TN-IKBM) by Title
Now showing items 438-457 of 498
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Synthesis of an Alleged Byproduct Precursor in Iodixanol Preparation
(Peer reviewed; Journal article, 2018-07)N1,N3-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-(oxiran-2-ylmethyl)acetamido)isophthalamide (1), the alleged precursor of several minor byproducts formed when the X-ray contrast agent iodixanol is synthesized from ... -
Synthesis of Biologically Active Iminosugars and Strategies Towards the Preparation of Chiral Quinoline Derivatives
(PhD thesis UiS;, Doctoral thesis, 2021-12)Design and preparation of novel bioactive compounds for development of new drug leads is a challenging task. Chirality plays a key role in all biological systems, including drug targets, and stereoisomeric compounds often ... -
Synthesis of Iminosugar Based Ammonium Compounds as Acetylcholinesterase Inhibitor Candidates – A Potential Strategy for Alzheimer’s Treatment
(Bachelor thesis, 2021)Alzheimer’s disease accounts for 60–70% of cases of dementia worldwide, with an estimated global incidence of 50 million cases. Alzheimer’s disease is a chronic and fatal illness that causes progressive deterioration of ... -
Synthesis of isocryptolepine and analogues for antimalarial evaluation
(Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-07)Malaria is considered a serious global health concern, causing 445 000 deaths annually. With the increasing apperance of drug resistant cases of Plasmodium strains, discovery of new treatments are of paramount importance. ... -
Synthesis of Phenacene−Helicene Hybrids by Directed Remote Metalation
(Peer reviewed; Journal article, 2020-08)Polycyclic aromatic hydrocarbons (PAHs) with six and seven rings were synthesized via directed metalation and cross-coupling of chrysenyl N,N-diethyl carboxamides with o-tolyl and methylnaphthalenyl derivatives. In the ... -
Synthesis of tacrine- and coumarin-isocryptolepine hybrids as potential dual binding site acetylcholinesterase inhibitors
(Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-08-10)This project presents the synthesis of tacrine and coumarin scaffolds armed with an alkyl-chain of varying length with an azido functionality and isocryptolepine scaffold armed with a terminal alkyne. The synthesis of ... -
Synthesis of the Hexahydropyrrolo‐[3,2‐c]‐quinoline Core Structure and Strategies for Further Elaboration to Martinelline, Martinellic Acid, Incargranine B, and Seneciobipyrrolidine
(Peer reviewed; Journal article, 2021-01)Natural products are rich sources of interesting scaffolds possessing a plethora of biological activity. With the isolation of the martinella alkaloids in 1995, namely martinelline and martinellic acid, the pyrrolo[3,2‐c]quinoline ... -
Synthesis of trans-dihydronaphthalene-diol and evaluation of their use as standards for PAH metabolite analysis in fish bile by GC-MS
(Peer reviewed; Journal article, 2020-05)Phenols and trans-1,2-dihydro-1,2-diols are metabolites commonly formed in vivo in fish upon exposure to polycyclic aromatic hydrocarbons (PAHs). These metabolites are excreted via the bile and gas chromatography-mass ... -
Synthesis, Characterization and Performance Testing of Environmental Acceptable Demulsifiers
(Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-07-15)Separation of crude oil from production water has been one of the first and most important challenges of the oil and gas industry. The dehydration of the crude oil is required to meet transportation and selling standards, ... -
Synthesis, characterization, and Batch adsorption analysis of Spent coffee grounds, Chitosan, and PVA composite beads for the removal of Cadmium and Lead from aqueous solutions.
(Master thesis, 2021)Adsorption of Cadmium and Lead in aqueous solutions by Spent coffee grounds/chitosan/PVA composite beads was studied. An adsorption Batch experimental model was used to determine the Isotherms and kinetics of 4 different ... -
A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease
(Peer reviewed; Journal article, 2021-07)There is great heterogeneity in both the clinical presentation and rate of disease progression among patients with Parkinson’s disease (PD). This can pose prognostic difficulties in a clinical setting, and a greater ... -
A systems biology approach to cellular homeostasis, volume changes and regulation of metabolism
(PhD thesis UiS;509, Doctoral thesis, 2020-04)Cells need to respond to a vast range of different disturbances and changes over small and large time scales. This can be disturbances in the form of molecules used to fight infectious states, changes in growth patterns, ... -
Tacrine hybrids as multi-target-directed ligands against Alzheimer’s disease
(Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-07)World health organization estimates that nearly 9.9 million people develop dementia each year. Alzheimer disease (AD) is the most common form of dementia, and contributes to 60-70% of the cases. In addition to affecting ... -
Technology-Enabled Smart Biomaterials for Food Packaging Systems and Edible Coating
(Master thesis, 2022)The rising awareness on the environmental impact of conventional plastics and the rapid pace of food innovation have shifted the interest towards biodegradable, smart food packaging materials using biopolymers (e.g. alginate) ... -
A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment
(Peer reviewed; Journal article, 2021)Background In colon cancer, the location and density of tumor-infiltrating lymphocytes (TILs) can classify patients into low and high-risk groups for prognostication. While a commercially available ‘Immunoscore®’ exists, ... -
Testing av THF-hydratinhibering og optimalisering av kjent testmetode
(Bachelor thesis, 2022)Dette prosjektet besto av syv delprosjekter som alle handlet THF-hydratinhibering. I de fleste delprosjektene ble ulike typer kjemiske stoffer testet som inhibitorer, og i noen av disse ble det utført syntese av nye eller ... -
Texture modified and enriched products to elderly and people with dysphagia
(Master thesis, 2021)The main aim for this thesis was to develop products with defined texture and viscosity properties for elderly people and dysphagia patients at Stavanger Universitets Sykehus (SUS). Two products were developed: 1) a texture ... -
Texture-modified salmon products for dysphagia patients
(Bachelor thesis, 2023)Consuming food plays an important role in a person's quality of life. Dysphagia is a medical condition where chewing and swallowing are difficult, and this condition is most common among the elderly. It can lead to ... -
The crystal structure of haemoglobin from Atlantic cod
(Journal article; Peer reviewed, 2019-06)The crystal structure of haemoglobin from Atlantic cod has been solved to 2.54 Å resolution. The structure consists of two tetramers in the crystallographic asymmetric unit. The structure of haemoglobin obtained from one ... -
The effect of benzalkonium chloride exposure on the minimum inhibitory concentration, and the spread of resistance to tetracycline in a laboratory-scale sludge reactor
(Bachelor thesis, 2022)With the increased use of disinfectants due to the Covid-19 pandemic an increased understanding of their effect on antimicrobial resistance is of paramount importance. This study looks at the effect low concentrations of ...