Blar i Department of Chemistry, Bioscience and Environmental Engineering (TN-IKBM) på forfatter "Sydnes, Magne Olav"
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Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioiso-Mers for Antimalarial, Antiproliferative and Antimicrobial Activities
Håheim, Katja Stangeland; Lindback, Emil; Tan, Kah Ni; Albrigtsen, Marte; Helgeland, Ida Therese Urdal; Clemence, Lauga; Matringe, Theodora; Kennedy, Emily K.; Andersen, Jeanette Hammer; Avery, Vicky M.; Sydnes, Magne Olav (Peer reviewed; Journal article, 2021-05)A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the ... -
Synthesis and Photodecomposition Studies of Photodegradable Antibiotics and Chitin Synthase Inhibitors
Eikemo, Vebjørn (PhD thesis UiS;, Doctoral thesis, 2022-05)The release of bioactive compounds to the biosphere, such as chitin synthase inhibitors that are causing negative effects in non-target organisms, or antibiotic agents that contribute to increasing antimicrobial resistance, ... -
Synthesis of an Alleged Byproduct Precursor in Iodixanol Preparation
Haarr, Marianne Bore; Lindback, Emil; Håland, Torfinn; Sydnes, Magne Olav (Peer reviewed; Journal article, 2018-07)N1,N3-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-(oxiran-2-ylmethyl)acetamido)isophthalamide (1), the alleged precursor of several minor byproducts formed when the X-ray contrast agent iodixanol is synthesized from ... -
Synthesis of Biologically Active Iminosugars and Strategies Towards the Preparation of Chiral Quinoline Derivatives
Haarr, Marianne Bore (PhD thesis UiS;, Doctoral thesis, 2021-12)Design and preparation of novel bioactive compounds for development of new drug leads is a challenging task. Chirality plays a key role in all biological systems, including drug targets, and stereoisomeric compounds often ... -
Synthesis of isocryptolepine and analogues for antimalarial evaluation
Håheim, Katja Stangeland (Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-07)Malaria is considered a serious global health concern, causing 445 000 deaths annually. With the increasing apperance of drug resistant cases of Plasmodium strains, discovery of new treatments are of paramount importance. ... -
Synthesis of the Hexahydropyrrolo‐[3,2‐c]‐quinoline Core Structure and Strategies for Further Elaboration to Martinelline, Martinellic Acid, Incargranine B, and Seneciobipyrrolidine
Haarr, Marianne Bore; Sydnes, Magne Olav (Peer reviewed; Journal article, 2021-01)Natural products are rich sources of interesting scaffolds possessing a plethora of biological activity. With the isolation of the martinella alkaloids in 1995, namely martinelline and martinellic acid, the pyrrolo[3,2‐c]quinoline ... -
Synthesis of trans-dihydronaphthalene-diol and evaluation of their use as standards for PAH metabolite analysis in fish bile by GC-MS
Vaaland, Ingrid Caroline; Pampanin, Daniela Maria; Sydnes, Magne Olav (Peer reviewed; Journal article, 2020-05)Phenols and trans-1,2-dihydro-1,2-diols are metabolites commonly formed in vivo in fish upon exposure to polycyclic aromatic hydrocarbons (PAHs). These metabolites are excreted via the bile and gas chromatography-mass ... -
The crystal structure of haemoglobin from Atlantic cod
Helland, Ronny; Bjørkeng, Eva Katrin; Rothweiler, Ulli; Sydnes, Magne Olav; Pampanin, Daniela Maria (Journal article; Peer reviewed, 2019-06)The crystal structure of haemoglobin from Atlantic cod has been solved to 2.54 Å resolution. The structure consists of two tetramers in the crystallographic asymmetric unit. The structure of haemoglobin obtained from one ...