Blar i Department of Chemistry, Bioscience and Environmental Engineering (TN-IKBM) på forfatter "Gudlaugsson, Einar"
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Better prognostic markers for nonmuscle invasive papillary urothelial carcinomas
Kvikstad, Vebjørn (PhD thesis UiS;, Doctoral thesis, 2022-04)Bladder cancer is a common type of cancer, especially among men in developed countries. Most cancers in the urinary bladder are papillary urothelial carcinomas. They are characterized by a high recurrence frequency (up to ... -
From Research to Clinical Diagnostics: Developing and Validating Biomarkers and Artificial Intelligence for Pathology
Rewcastle, Emma (PhD thesis UiS;, Doctoral thesis, 2024)In 2021, digital pathology was deployed in the hospitals of the western health region of Norway. Histological tissue specimens previously viewed under the microscope on glass slides, are now being scanned, and whole slide ... -
Homologous Recombination Deficiency Across Subtypes of Primary Breast Cancer
Yndestad, Synnøve; Engebrethsen, Christina; Herencia-Ropero, A.; Nikolaienko, Oleksii; Vintermyr, Olav Karsten; Lillestøl, Reidun Kristine; Minsaas, Laura; Leirvaag, Beryl; Iversen, Gjertrud Titlestad; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Aase, Hildegunn Siv; Aas, Turid; Gudlaugsson, Einar; Llop-Guevara, Alba; Serra, Violeta; Janssen, Emiel; Lønning, Per Eystein; Knappskog, Stian; Eikesdal, Hans Petter (Peer reviewed; Journal article, 2023)Purpose Homologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of HRD in non-TNBC to ... -
Mitotic activity index and CD25+ lymphocytes predict risk of stage progression in non-muscle invasive bladder cancer
Lillesand, Melinda; Kvikstad, Vebjørn; Mangrud, Målfrid Ok; Gudlaugsson, Einar; Van Diermen, Bianca; Skaland, Ivar; Baak, Johannes Peter A; Janssen, Emiel (Peer reviewed; Journal article, 2020-06)In urothelial cell type non-muscle invasive urinary bladder carcinoma, TNM stage and WHO grade are widely used to classify patients into low and high-risk groups for prognostic and therapeutic decision-making. However, ... -
Prognostic value and reproducibility of different microscopic characteristics in the WHO grading systems for pTa and pT1 urinary bladder urothelial carcinomas
Kvikstad, Vebjørn; Mangrud, Målfrid Ok; Gudlaugsson, Einar; Dalen, Ingvild; Espeland, Hans; Baak, Jan P.A.; Janssen, Emiel (Peer reviewed; Journal article, 2019-08)Background: European treatment guidelines for pTa and pT1 urinary bladder urothelial carcinoma depend highly on stage and WHO-grade. Both the WHO73 and the WHO04 grading systems show some intra- and interobserver variability. ... -
A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment
Lea, Dordi; Watson, Martin Matthew Christian; Skaland, Ivar; Hagland, Hanne Røland; Lillesand, Melinda; Gudlaugsson, Einar; Søreide, Kjetil (Peer reviewed; Journal article, 2021)Background In colon cancer, the location and density of tumor-infiltrating lymphocytes (TILs) can classify patients into low and high-risk groups for prognostication. While a commercially available ‘Immunoscore®’ exists, ... -
Validation study of MARCKSL1 as a prognostic factor in lymph node-negative breast cancer patients
Egeland, Nina Gran; Austdal, Marie; Van Diermen, Bianca; Rewcastle, Emma; Gudlaugsson, Einar; Baak, Jan P.A.; Skaland, Ivar; Janssen, Emiel; Jonsdottir, Kristin (Peer reviewed; Journal article, 2019)Protein expression of Myristoylated alanine-rich C kinase substrate like-1 (MARCKSL1) has been identified as a prognostic factor in lymph-node negative (LN-) breast cancer patients. We aim to validate MARCKSL1 protein ...