Browsing Department of Chemistry, Bioscience and Environmental Engineering (TN-IKBM) by Author "Søreide, Kjetil"
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Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines
Tidwell, Tia R.; Røsland, Gro Vatne; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne Røland (Peer reviewed; Journal article, 2022-05)Background Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the ... -
A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment
Lea, Dordi; Watson, Martin Matthew Christian; Skaland, Ivar; Hagland, Hanne Røland; Lillesand, Melinda; Gudlaugsson, Einar; Søreide, Kjetil (Peer reviewed; Journal article, 2021)Background In colon cancer, the location and density of tumor-infiltrating lymphocytes (TILs) can classify patients into low and high-risk groups for prognostication. While a commercially available ‘Immunoscore®’ exists, ...