Blar i Department of Chemistry, Bioscience and Environmental Engineering (TN-IKBM) på tidsskrift "PLOS ONE"
Viser treff 1-12 av 12
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An amplified derepression controller with multisite inhibition and positive feedback
(Peer reviewed; Journal article, 2021-03)How organisms are able to maintain robust homeostasis has in recent years received increased attention by the use of combined control engineering and kinetic concepts, which led to the discovery of robust controller motifs. ... -
Coherent feedback leads to robust background compensation in oscillatory and non-oscillatory homeostats
(Peer reviewed; Journal article, 2023-08)When in a reaction kinetic integral controller a step perturbation is applied besides a constant background, the concentration of a controlled variable (described as A) will generally respond with decreased response ... -
DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water
(Peer reviewed; Journal article, 2020)The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by ... -
Frequency switching between oscillatory homeostats and the regulation of p53
(Peer reviewed; Journal article, 2020-05)Homeostasis is an essential concept to understand the stability of organisms and their adaptive behaviors when coping with external and internal assaults. Many hormones that take part in homeostatic control come in ... -
Homeostasis at different backgrounds: The roles of overlayed feedback structures in vertebrate photoadaptation
(Peer reviewed; Journal article, 2023)We have studied the resetting behavior of eight basic integral controller motifs with respect to different but constant backgrounds. We found that the controllers split symmetrically into two classes: one class, based on ... -
Homeostatic controllers compensating for growth and perturbations
(Journal article; Peer reviewed, 2019-08)Cells and organisms have developed homeostatic mechanisms which protect them against a changing environment. How growth and homeostasis interact is still not well understood, but of increasing interest to the molecular and ... -
Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
(Peer reviewed; Journal article, 2022)Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased ... -
Major bioactive chemical compounds in Astragali Radix samples from different vendors vary greatly
(Peer reviewed; Journal article, 2021-07)The worldwide traditional Chinese medicine (TCM) herbs sales figures have increased considerably to 50 billion US$ (2018). Astragali Radix (AR) is amongst the most often sold TCM herbs; sales in the European Union (EU) ... -
Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci
(Peer reviewed; Journal article, 2020-10)Parkinson disease (PD) is a complex neurodegenerative disorder influenced by both environmental and genetic factors. While genome wide association studies have identified several susceptibility loci, many causal variants ... -
Mitotic activity index and CD25+ lymphocytes predict risk of stage progression in non-muscle invasive bladder cancer
(Peer reviewed; Journal article, 2020-06)In urothelial cell type non-muscle invasive urinary bladder carcinoma, TNM stage and WHO grade are widely used to classify patients into low and high-risk groups for prognostic and therapeutic decision-making. However, ... -
Plasma-derived exosome-like vesicles are enriched in lyso-phospholipids and pass the blood-brain barrier
(Peer reviewed; Journal article, 2020-09)Exosomes are vesicles involved in intercellular communication. Their membrane structure and core content is largely dependent on the cell of origin. Exosomes have been investigated both for their biological roles and their ... -
Validation study of MARCKSL1 as a prognostic factor in lymph node-negative breast cancer patients
(Peer reviewed; Journal article, 2019)Protein expression of Myristoylated alanine-rich C kinase substrate like-1 (MARCKSL1) has been identified as a prognostic factor in lymph-node negative (LN-) breast cancer patients. We aim to validate MARCKSL1 protein ...