Blar i Department of Chemistry, Bioscience and Environmental Engineering (TN-IKBM) på emneord "VDP::Matematikk og Naturvitenskap: 400::Kjemi: 440"
Viser treff 1-20 av 75
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1,4-Dideoxy-1,4-imino‑D‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitors
(Peer reviewed; Journal article, 2020-07)The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase ... -
3D in vitro cancer models for drug screening: A study of glucose metabolism and drug response in 2D and 3D culture models
(PhD thesis UiS;, Doctoral thesis, 2022-03)Current drug screening protocols use in vitro cancer cell panels grown in 2D to evaluate drug response and select the most promising candidates for further in vivo testing. Most drug candidates fail at this stage, not ... -
Antiscaling Evaluation and Quantum Chemical Studies of Nitrogen-Free Organophosphorus Compounds for Oilfield Scale Management
(Peer reviewed; Journal article, 2021-08)Nonpolymeric aminomethylenephosphonates are widely used as powerful scale inhibitors in the petroleum industry. However, most of these inhibitors have certain drawbacks, such as low biodegradability and incompatibilities ... -
Boronic and Organic Acids as Synergists for a Poly(N-vinylcaprolactam) Kinetic Hydrate Inhibitor
(Peer reviewed; Journal article, 2021-12)A range of boronic acids have been investigated as synergists for the kinetic hydrate inhibitor (KHI) polymer, poly(N-vinylcaprolactam) (PVCap, Mw ≈ 10,000 g/mol) using high pressure rocking cells, a natural gas mixture, ... -
Cavity Size Effects on the Adsorption of CO2 on Pillar[n]arene Structures: A Density Functional Theory Study
(Peer reviewed; Journal article, 2023-08)Carbon dioxide (CO2) is the main greenhouse gas that contributes to the global warming. Therefore, CO2 adsorption is very urgent in the fight to limit global warming below 1.5 degrees Celsius. In this report, the interaction ... -
Characterization of Norwegian blood culture isolates of Klebsiella pneumoniae using whole genome sequencing
(Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-06)The increasing trend of antimicrobial resistance (AMR) has been acknowledged by the world health organization (WHO) as an urgent threat to public health. Especially the development of multi drug resistant (MDR) Gram-negative ... -
Combined Effect of Citric Acid and Polyphenol-Rich Grape Seed Extract towards Bioactive Smart Food Packaging Systems
(Peer reviewed; Journal article, 2023-07)Alginate films (2% w·v−1) were prepared with varying concentrations (5–20% w/w) of citric acid and aqueous grape seed extract (GSE) filtrate (11.66 ± 1.32 g GAE/L) using the solvent-evaporation method. Crosslinking alginate ... -
Combined Effect of Citric Acid and Polyphenol-Rich Grape Seed Extract towards Bioactive Smart Food Packaging Systems
(Peer reviewed; Journal article, 2023-07)Alginate films (2% w·v−1) were prepared with varying concentrations (5–20% w/w) of citric acid and aqueous grape seed extract (GSE) filtrate (11.66 ± 1.32 g GAE/L) using the solvent-evaporation method. Crosslinking alginate ... -
Design, Synthesis, Anticancer Evaluation, Enzymatic Assays, and a Molecular Modeling Study of Novel Pyrazole−Indole Hybrids
(Peer reviewed; Journal article, 2021-04)The molecular hybridization concept has recently emerged as a powerful approach in drug discovery. A series of novel indole derivatives linked to the pyrazole moiety were designed and developed via a molecular hybridization ... -
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
(Peer reviewed; Journal article, 2021-07)The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters ... -
Diastereoselectivity in Anomeric O-alkylation Glycosylation
(PhD thesis UiS;, Doctoral thesis, 2021-02)Biosynth AS used anomeric O-alkylation of α-haloacetophenones in their patented total synthesis of anthocyanins from 2006. There were, however, several challenges with stereoselectivity and yields when performing this ... -
Distinct Clades of Protein Phosphatase 2A Regulatory B’/B56 Subunits Engage in Different Physiological Processes
(Peer reviewed; Journal article, 2023-07)Protein phosphatase 2A (PP2A) is a strongly conserved and major protein phosphatase in all eukaryotes. The canonical PP2A complex consists of a catalytic (C), scaffolding (A), and regulatory (B) subunit. Plants have three ... -
Divergent Synthesis of Indolo[3,2- c]quinolines, Neocryptolepines and Related Tetracyclic Ring-Systems Containing Promising Biological Activities
(PhD thesis UiS;, Doctoral thesis, 2022)Malaria is a devastating tropical disease, claiming approximately 627 000 lives in 2020. Due to the appearance of resistance towards artemisinin-based therapies, the discovery of novel treatments are of paramount ... -
DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water
(Peer reviewed; Journal article, 2020)The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by ... -
DOPA Homeostasis by Dopamine: A Control-Theoretic View
(Peer reviewed; Journal article, 2021-11)Dopamine (DA) is an important signal mediator in the brain as well as in the periphery. The term “dopamine homeostasis” occasionally found in the literature refers to the fact that abnormal DA levels can be associated with ... -
An economic and environmental analysis of greenhouse tomato production in Norway using a model-based technique
(PhD thesis UiS;, Doctoral thesis, 2022-12)The growing global population levels and the resulting increasing demands for food has put a lot of pressure on the food production systems and made the agricultural sector highly energy-intensive. The intensification in ... -
Environmentally Friendly Phosphonated Polyetheramine Scale Inhibitors - Excellent Calcium Compatibility for Oilfield Applications
(Peer reviewed; Journal article, 2020-05)Scaling is one of the most frequently stated problems in the oil industry, and scale inhibitors (SIs) are applied to prevent its formation. Organophosphonates are well-known types of SIs, particularly useful for squeeze ... -
Evaluation of photodegradable chitin synthetase inhibitors for the treatment of salmon lice (Lepeophtheirus salmonis)
(Peer reviewed; Journal article, 2023)Some photolabile ethanolamine analogues of the chitin synthetase inhibitors diflubenzuron, teflubenzuron, and lufenuron were tested for activity as anti-lice compounds towards salmon lice (Lepeophtheirus salmonis). Two ... -
Exploring Modified Alendronic Acid as a New Inhibitor for Calcium-Based Oilfield Scales
(Peer reviewed; Journal article, 2022-02)Organophosphorus compounds are well known as oilfield scale inhibitors. Earlier work showed that a series of new and well-known bone-targeting drugs incorporating non-toxic bisphosphonates (BPs) (PO3H2–C–PO3H2) gave good ... -
Field test investigation of the performance of corrosion inhibitors: a case study
(Peer reviewed; Journal article, 2021-09)Corrosion is considered one of the major problems that affect flow assurance during hydrocarbon production. This irreversible phenomenon has the ability to cause serious material failure in the oil and gas industry. ...