Blar i Vitenskapelige publikasjoner (TN-IKBM) på tittel

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    • Differential transcript usage in the Parkinson’s disease brain 

      Dick, Fiona; Sanchez Nido, Gonzalo; Alves, Guido Werner; Tysnes, Ole-Bjørn; Nilsen, Gry Hilde; Dölle, Christian; Tzoulis, Charalampos (Peer reviewed; Journal article, 2020)
      Studies of differential gene expression have identified several molecular signatures and pathways associated with Parkinson’s disease (PD). The role of isoform switches and differential transcript usage (DTU) remains, ...

    • Directed ortho-Metalation and Anionic ortho-Fries Rearrangement of Polycyclic Aromatic O-Carbamates: Regioselective Synthesis of Substituted Chrysenes 

      Kancherla, Sindhu; Lorentzen, Marianne; Snieckus, Victor; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2018-03)
      A general method for the regioselective synthesis of a series of ortho-substituted chrysenyl N,N-diethyl-O-carbamates by the directed ortho-metalation (DoM) strategy is reported. The starting O-carbamates were prepared ...

    • Distinct Clades of Protein Phosphatase 2A Regulatory B’/B56 Subunits Engage in Different Physiological Processes 

      Heidariahootapeh, Behzad; Nemie-Feyissa, Dugassa; Lillo, Cathrine (Peer reviewed; Journal article, 2023-07)
      Protein phosphatase 2A (PP2A) is a strongly conserved and major protein phosphatase in all eukaryotes. The canonical PP2A complex consists of a catalytic (C), scaffolding (A), and regulatory (B) subunit. Plants have three ...

    • Distinct Gene Expression Profiles of Matched Primary and Metastatic Triple-Negative Breast Cancers 

      Kaur, Jaspreet; Chandrashekar, Darshan S.; Varga, Zsuzsanna; Sobottka, Bettina; Janssen, Emiel; Kowalski, Jeanne; Kiraz, Umay; Varambally, Sooryanarayana; Aneja, Ritu (Peer reviewed; Journal article, 2022)
      Background: Although triple-negative breast cancer (TNBC) is associated with an increased risk of recurrence and metastasis, the molecular mechanisms underlying metastasis in TNBC remain unknown. To identify transcriptional ...

    • DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water 

      Meier, Sonnich; Karlsen, Ørjan; Le Goff, Jérémie; Sørensen, Lisbet; Sørhus, Elin; Pampanin, Daniela Maria; Donald, Carey E.; Fjelldal, Per Gunnar; Dunaevskaya, Evgenia; Romano, Marta; Caliani, Ilaria; Casini, Silvia; Bogevik, Andre S.; Olsvik, Pål Asgeir; Myers, Mark; Grøsvik, Bjørn Einar (Peer reviewed; Journal article, 2020)
      The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by ...

    • DOPA Homeostasis by Dopamine: A Control-Theoretic View 

      Kleppe, Rune; Waheed, Qaiser; Ruoff, Peter (Peer reviewed; Journal article, 2021-11)
      Dopamine (DA) is an important signal mediator in the brain as well as in the periphery. The term “dopamine homeostasis” occasionally found in the literature refers to the fact that abnormal DA levels can be associated with ...

    • Early constipation predicts faster dementia onset in Parkinson's disease 

      Camacho, Marta; Macleod, Angus D.; Grødem, Jodi Maple; Evans, Jonathan R.; Breen, David P.; Cummins, G; Wijeyekoon, Ruwani; Greenland, Julia; Alves, Guido Werner; Tysnes, Ole-Bjørn; Lawson, Rachel A.; Barker, Roger A.; Williams-Gray, Caroline H. (Peer reviewed; Journal article, 2021-05)
      Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s ...

    • Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease 

      Flønes, Irene Hana; Nyland, Harald Inge; Sandnes, Dagny Ann; Alves, Guido Werner; Tysnes, Ole-Bjørn; Tzoulis, Charalampos (Peer reviewed; Journal article, 2022)
      Idiopathic Parkinson’s disease (iPD) is characterized by degeneration of the dopaminergic substantia nigra pars compacta (SNc), typically in the presence of Lewy pathology (LP) and mitochondrial respiratory complex I (CI) ...

    • Effect of Dispersion Treatment on Dairy Waste Activated Sludge to Hasten the Production of Biogas 

      Rufus, D.P.; Banu, J. Rajesh; Kannah, R. Yukesh; Nguyen, Dinh Duc; Kumar, Gopalakrishnan; Chang, Soon Woong; Raja, S. Antony (Peer reviewed; Journal article, 2019)
      The solubilization potential of biological pre-treatment for waste activated sludge (WAS) is limited due to the floc structure of the WAS. Extra polymeric substances (EPS) are responsible for floc formation. In this ...

    • Effect of low temperature and municipal wastewater organic loading on anaerobic granule reactor performance 

      Safitri, Anissa Sukma; Kaster, Krista Michelle; Kommedal, Roald (Peer reviewed; Journal article, 2022)
      Biogas production and municipal wastewater COD removal at low temperatures by granulated anaerobic biomass were investigated. Two anaerobic granule reactors were operated continuously for 1025 days by stepwise increase of ...

    • Effect of temperatures on anaerobic granulated biofilm modelling 

      Safitri, Anissa Sukma; Kommedal, Roald (Peer reviewed; Journal article, 2022)
      Anaerobic granulated biomass-based treatment is a sustainable alternative for municipal wastewater treatment. Each granule in the system is comprised of a complex community of anaerobic microorganisms embedded in a biofilm ...

    • Effective recovery of microalgal biomass using various types of emulsion polymers 

      Huy, Menghour; Kumar, Gopalakrishnan; Sharma, Pooja; Sirohi, Ranjna; Pandey, Ashok; Kim, Sang-Hyoun (Peer reviewed; Journal article, 2022)
      Microalgae biomass has been considered as one of the potential feedstocks in biofuel production. Yet, biomass harvesting poses a challenge to the overall production cost due to its low cell density. Flocculation has been ...

    • Engineered methanotrophic syntrophy in photogranule communities removes dissolved methane 

      Safitri, Anissa Sukma; Hamelin, Jerome; Kommedal, Roald; Milferstedt, Kim (Peer reviewed; Journal article, 2021-06)
      The anaerobic treatment of wastewater leads to the loss of dissolved methane in the effluent of the treatment plant, especially when operated at low temperatures. The emission of this greenhouse gas may reduce or even ...

    • Enrofloxacin Induces Intestinal Microbiota-Mediated Immunosuppression in Zebrafish 

      Qiu, Wenhui; Liu, Tang; Liu, Xinjie; Chen, Honghong; Luo, Shusheng; Chen, Qiqing; Magnuson, Jason Tyler; Zheng, Chunmiao; Xu, Elvis Genbo; Schlenk, Daniel (Journal article; Peer reviewed, 2022-05-12)
      The immunosuppressive effects of antibiotics and the potential associations with the intestinal microbiota of the host have been increasingly recognized in recent years. However, the detailed underlying mechanisms of immune ...

    • Environmentally Friendly Phosphonated Polyetheramine Scale Inhibitors - Excellent Calcium Compatibility for Oilfield Applications 

      Mady, Mohamed Fawzy Hamed Attia; Bayat, Parya; Kelland, Malcolm A. (Peer reviewed; Journal article, 2020-05)
      Scaling is one of the most frequently stated problems in the oil industry, and scale inhibitors (SIs) are applied to prevent its formation. Organophosphonates are well-known types of SIs, particularly useful for squeeze ...

    • The escherichia coli alkA gene is activated to alleviate mutagenesis by an oxidized deoxynucleoside 

      Grøsvik, Kristin; Tesfahun, Almaz Nigatu; Muruzábal-Lecumberri, Izaskun; Haugland, Gyri Teien; Leiros, Ingar; Ruoff, Peter; Kvaløy, Jan Terje; Knævelsrud, Ingeborg; Ånensen, Hilde; Alexeeva, Marina; Sato, Kousuke; Matsuda, Akira; Alseth, Ingrun; Klungland, Arne; Bjelland, Svein (Peer reviewed; Journal article, 2020)
      The cellular methyl donor S-adenosylmethionine (SAM) and other endo/exogenous agents methylate DNA bases non-enzymatically into products interfering with replication and transcription. An important product is 3-methyladenine ...

    • Estimating diagnostic uncertainty in artificial intelligence assisted pathology using conformal prediction 

      Olsson, Henrik; Kartasalo, Kimmo; Mulliqi, Nita; Capuccini, Marco; Ruusuvuori, Pekka; Samaratunga, Hemamali; Delahunt, Brett; Lindskog, Cecilia; Janssen, Emiel; Blilie, Anders; Egevad, Lars; Spjuth, Ola; Eklund, Martin (Peer reviewed; Journal article, 2022)
      Unreliable predictions can occur when an artificial intelligence (AI) system is presented with data it has not been exposed to during training. We demonstrate the use of conformal prediction to detect unreliable predictions, ...

    • Evaluation of photodegradable chitin synthetase inhibitors for the treatment of salmon lice (Lepeophtheirus salmonis) 

      Sydnes, Magne Olav; Eikemo, Vebjørn; Espedal, Per Gunnar; Sydnes, Leiv K.; Nilsen, Frank (Peer reviewed; Journal article, 2023)
      Some photolabile ethanolamine analogues of the chitin synthetase inhibitors diflubenzuron, teflubenzuron, and lufenuron were tested for activity as anti-lice compounds towards salmon lice (Lepeophtheirus salmonis). Two ...

    • Evolutionary analysis of cellular reduction and anaerobicity in the hyper-prevalent gut microbe Blastocystis 

      Záhonová, Kristína; Low, Ross S.; Warren, Christopher J.; Cantoni, Diego; Herman, Emily K.; Yiangou, Lyto; Ribeiro, Cláudia A.; Phanprasert, Yasinee; Brown, Ian R.; Rueckert, Sonja; Baker, Nicola L.; Tachezy, Jan; Betts, Emma L.; Gentekaki, Eleni; van der Giezen, Mark; Clark, C. Graham; Jackson, Andrew P.; Dacks, Joel B.; Tsaousis, Anastasios D. (Peer reviewed; Journal article, 2023)
      Blastocystis is the most prevalent microbial eukaryote in the human and animal gut, yet its role as commensal or parasite is still under debate. Blastocystis has clearly undergone evolutionary adaptation to the gut environment ...

    • Evolutionary Maintenance of the PTS2 Protein Import Pathway in the Stramenopile Alga Nannochloropsis 

      Kechasov, Dmitry; de Grahl, Imke; Endries, Pierre; Reumann, Sigrun (Peer reviewed; Journal article, 2020)
      The stramenopile alga Nannochloropsis evolved by secondary endosymbiosis of a red alga by a heterotrophic host cell and emerged as a promising organism for biotechnological applications, such as the production of polyunsaturated ...