Blar i Vitenskapelige publikasjoner (TN-IKBM) på tittel

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    • Identification of Arabidopsis Protein Kinases That Harbor Functional Type 1 Peroxisomal Targeting Signals 

      Kataya, Amr Ramzy Abass; Gautam, Nitija; Jamshed, Muhammad; Muench, Douglas G.; Samuel, Marcus A.; Thelen, Jay J.; Moorhead, Greg B. (Peer reviewed; Journal article, 2022)
      Peroxisomes are eukaryotic specific organelles that perform diverse metabolic functions including fatty acid β-oxidation, reactive species metabolism, photorespiration, and responses to stress. However, the potential ...

    • Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach 

      Maple-Grødem, Jodi; Ushakova, Anastasia; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2023-10)
      Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ...

    • Identification of diagnostic and prognostic biomarkers of PD using a multiplex proteomics approach 

      Maple-Grødem, Jodi; Ushakova, Anastasia; Pedersen, Kenn Freddy; Tysnes, Ole-Bjørn; Alves, Guido Werner; Lange, Johannes (Peer reviewed; Journal article, 2023-09)
      Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of ...

    • Impact of KRAS and BRAF mutations on treatment efficacy and survival in high-grade gastroenteropancreatic neuroendocrine neoplasms 

      Elvebakken, Hege; Hjortland, Geir Olav; Garresori, Herish; Andresen, Per Arne; Janssen, Emiel; Vintermyr, Olav Karsten; Lothe, Inger Marie Bowitz; Sorbye, Halfdan (Peer reviewed; Journal article, 2023)
      High-grade gastroenteropancreatic neuroendocrine neoplasms (HG GEP-NEN) typically disseminate early. Treatment of metastatic disease has limited benefit and prognosis is generally discouraging. Data on the clinical impact ...

    • Improved pH-Responsive Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide 

      Alhourani, Abdelnour; Førde, Jan-Lukas; Eichacker, Lutz Andreas; Herfindal, Lars; Hagland, Hanne Røland (Peer reviewed; Journal article, 2021-09)
      Graphene-based drug carriers provide a promising addition to current cancer drug delivery options. Increased accessibility of high-quality graphene made by plasma-enhanced chemical vapor deposition (PE-CVD) makes it an ...

    • Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway 

      Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live; Al-Shibli, Khalid Ibrahim; Andersson, Yvonne; Berg, Thomas; Bjørge, Line; Blix, Egil Støre; Bjerkehagen, Bodil; Brabrand, Sigmund; CAMERON, MARTE; Dalhaug, Astrid; Dietzel, Dalia; Dønnem, Tom; Enerly, Espen; Flobak, Åsmund; Fluge, Sverre; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Grønberg, Bjørn Henning; Grønås, Kari; Guren, Tormod Kyrre; Hamre, Hanne Mari; Haug, Åse; Heinrich, Daniel; Hjortland, Geir Olav; Hovig, Eivind; Hovland, Randi; Iversen, Ann-Charlotte; Janssen, Emiel; Kyte, Jon A; Gythfeldt, Hedda; Lothe, Ragnhild Adelheid; Lund, Jo-Åsmund; Meza, Leonardo Zepeda; Munthe-Kaas, Monica Cheng; Nguyen, Olav Toai Duc; Niehusmann, Pitt; Nilsen, Hilde; Puco, Katarina; Ree, Anne Hansen; Riste, Tonje Bøyum; Semb, Karin; Steinskog, Eli Sihn Samdal; Stensvold, Andreas; Suhrke, Pål; Tennøe, Øyvind Krohn; Tjønnfjord, Geir Erland; Vassbotn, Liv Jorunn; Aas, Eline; Aasebø, Kristine Øverås; Tasken, Kjetil; Smeland, Sigbjørn (Peer reviewed; Journal article, 2022)
      Background Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed ...

    • Impulsive and compulsive behaviors in Parkinson's disease: Impact on quality of and satisfaction with life, and caregiver burden 

      Erga, Aleksander Hagen; Alves, Guido Werner; Tysnes, Ole-Bjørn; Pedersen, Kenn Freddy (Peer reviewed; Journal article, 2020)
      To disentangle the association between impulsive and compulsive behaviors (ICBs), health-related quality of life (HRQOL), satisfaction with life (SwL), and caregiver distress in dyads of people with Parkinson's disease ...

    • In silico investigations of intratumoral heterogeneous interstitial fluid pressure 

      Waldeland, Jahn Otto; Gaustad, Jon-Vidar; Rofstad, Einar K; Evje, Steinar (Peer reviewed; Journal article, 2021-06)
      Recent preclinical studies have shown that interstitial fluid pressure (IFP) within tumors can be heterogeneous Andersen et al. (2019). In that study tumors of two xenograft models, respectively, HL-16 cervical carcinoma ...

    • The incidence, baseline predictors, and outcomes of dementia in an incident cohort of Parkinson’s disease and controls 

      Counsell, Carl; Giuntoli, Cinzia; Khan, Qaisar Imran; Maple-Grødem, Jodi; Macleod, Angus D. (Peer reviewed; Journal article, 2022)
      Background There are few long-term data on the incidence, baseline predictors, and outcomes of dementia in Parkinson’s disease (PD) from prospective community-based incident cohorts. Methods The PINE study prospectively ...

    • The influence of terrain on the mean wind flow characteristics in a fjord 

      Cheynet, Etienne; Liu, Shengnan; Ong, Muk Chen; Jakobsen, Jasna Bogunovic; Snæbjörnsson, Jonas Thor; gatin, Inno (Peer reviewed; Journal article, 2020)
      Flow conditions in complex terrains such as fjords are highly three-dimensional and thus not properly captured by the wind flow models developed for homogenous terrains. In the present study, we explore the potential of ...

    • Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers 

      Da Silva, Jessica; Leal, Ermelindo C.; Carvalho, Eugénia; Barros e Silva, Eduardo Alexandre (Peer reviewed; Journal article, 2023-06)
      The imbalance of local and systemic factors in individuals with diabetes mellitus (DM) delays, or even interrupts, the highly complex and dynamic process of wound healing, leading to diabetic foot ulceration (DFU) in 15 ...

    • Insights into the potential of the Atlantic cod gut microbiome as biomarker of oil contamination in the marine environment 

      Walter, Juline Marta; Bagi, Andrea; Pampanin, Daniela Maria (Peer reviewed; Journal article, 2019)
      Background: Microorganisms are widespread in all environments, including in and on animal bodies. The gut microbiome has an essential influence on fish health, and is affected by several persistent and harmful organic and ...

    • Integrated biorefineries for repurposing of food wastes into value-added products 

      Narisetty, Vivek; Adlakha, Nidhi; Kumar Singh, Navodit; Dalei, Sudipt Kumar; Prabhu, Ashish A; Nagarajan, Sanjay; Naresh Kumar, Kumar; Amruthraj Nagoth, Joseph; Kumar, Gopalakrishnan; Singh, Vijai; Kumar, Vinod (Peer reviewed; Journal article, 2022)
      Food waste (FW) generated through various scenarios from farm to fork causes serious environmental problems when either incinerated or disposed inappropriately. The presence of significant amounts of carbohydrates, proteins, ...

    • Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren's syndrome 

      Bårdsen, Kjetil; Brede, Cato; Kvivik, Ingeborg; Kvaløy, Jan Terje; Jonsdottir, Kristin; Tjensvoll, Anne Bolette; Ruoff, Peter; Omdal, Roald (Peer reviewed; Journal article, 2019)
      Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ...

    • Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification 

      Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar; Kirpekar, Finn; Klungland, Arne; Alsøe, Lene; Nilsen, Hilde; Bjelland, Svein (Peer reviewed; Journal article, 2021)
      Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed ...

    • Investigation of the Antiscaling Performance of Phosphonated Chitosan for Upstream Petroleum Industry Application 

      Mady, Mohamed Fawzy Hamed Attia; Abdel-Azeim, Safwat; Kelland, Malcolm Andrew (Peer reviewed; Journal article, 2021)
      Scale deposition is one of the main water-based production problems in the upstream oil and gas industry. Few environmentally friendly scale inhibitors show good thermal stability as well as calcium compatibility. We report ...

    • Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers 

      Vaaland, Ingrid Caroline; Lopez, Oscar; Puerta, Adrian; Fernandes, Miguel X.; Padron, Jose M.; Fernandez-Bolanos, Jose G.; Sydnes, Magne Olav; Lindback, Emil (Peer reviewed; Journal article, 2023-09)
      The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol ...

    • Kinase chemodiversity from the Arctic: the breitfussins 

      Østnes Hansen, Kine; Andersen, Jeanette hammer; Bayer, Annette; Pandey, Sunil Kumar; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe; Klebl, Bert; Eickhoff, Jan; Haug, Bengt Erik; Isaksson, Johan; Hansen, Espen (Journal article; Peer reviewed, 2019-10)
      In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C–H (3 ...

    • Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers 

      Waheed, Qaiser; Zhou, Huimin; Ruoff, Peter (Peer reviewed; Journal article, 2022)
      Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased ...

    • Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts 

      Grødem, Jodi Maple; Paul, Kimberly C.; Dalen, Ingvild; Ngo, Kathie J.; Wong, Darice; Macleod, Angus D.; Counsell, Carl E.; Bäckström, David; Forsgren, Lars; Tysnes, Ole-Bjørn; Kusters, Cynthia D.J.; Fogel, Brent L.; Bronstein, Jeff M.; Ritz, Beate; Alves, Guido Werner (Peer reviewed; Journal article, 2021)
      Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson’s disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on ...