Blar i Vitenskapelige publikasjoner (TN-IKBM) på forfatter "Jørgensen, Kåre Bredeli"
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Alkyl-phenanthrenes in early life stage fish: differential toxicity in Atlantic haddock (Melanogrammus aeglefinus) embryos
Donald, Carey; Nakken, Charlotte L.; Sørhus, Elin; Perrichon, Prescilla; Jørgensen, Kåre Bredeli; Bjelland, Hege Kristoffersen; Stølen, Christine; Kancherla, Sindhu; Mayer, Philipp; Meier, Sonnich (Peer reviewed; Journal article, 2023)Tricyclic polycyclic aromatic hydrocarbons (PAHs) are believed to be the primary toxic components of crude oil. Such compounds including phenanthrene are known to have direct effects on cardiac tissue, which lead to ... -
Atropisomerism in Tertiary Biaryl 2-Amides: A Study of Ar-CO and Ar-Ar? Rotational Barriers
Lorentzen, Marianne; Kalvet, Indrek; Sauriol, Francoise; Rantanen, Toni; Jørgensen, Kåre Bredeli; Snieckus, Victor (Peer reviewed; Journal article, 2017)A rotational barrier study was performed on eight tertiary biaryl 2-amides using variable temperature (VT) NMR and exchange (EXSY) spectroscopy experiments. Seven out of the eight 2-amido-2′-methylbiphenyls with additional ... -
Directed ortho-Metalation and Anionic ortho-Fries Rearrangement of Polycyclic Aromatic O-Carbamates: Regioselective Synthesis of Substituted Chrysenes
Kancherla, Sindhu; Lorentzen, Marianne; Snieckus, Victor; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2018-03)A general method for the regioselective synthesis of a series of ortho-substituted chrysenyl N,N-diethyl-O-carbamates by the directed ortho-metalation (DoM) strategy is reported. The starting O-carbamates were prepared ... -
Kinase chemodiversity from the Arctic: the breitfussins
Østnes Hansen, Kine; Andersen, Jeanette hammer; Bayer, Annette; Pandey, Sunil Kumar; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe; Klebl, Bert; Eickhoff, Jan; Haug, Bengt Erik; Isaksson, Johan; Hansen, Espen (Journal article; Peer reviewed, 2019-10)In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C–H (3 ... -
Oxidative synthesis of ortho-quinones from hydroxy-PAHs by stabilized formulation of 2-iodoxybenzoic acid (SIBX)
Tiruye, Hiwot Minwuyelet; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2022)Polycyclic aromatic phenols (PAPs or hydroxy-PAHs) are conveniently converted into their corresponding ortho-quinones using commercially available stabilized iodoxybenzoic acid (SIBX). SIBX provides a safer and commercially ... -
Regiospecific Photochemical Synthesis of Methylchrysenes
Bøhme, Thomas Andre; Egeland, Mari; Lorentzen, Marianne; Mady, Mohamed Fawzy Hamed Attia; Solbakk, Michelle F.; Sæbø, Krister Samsonsen; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2022-12)Methylated polycyclic aromatic hydrocarbons (PAHs) are suspected to be some of the toxic compounds in crude oil towards marine life and are needed as single compounds for environmental studies. 1-, 3- and 6-methylchrysene ... -
Relationships between Isomeric Metabolism and Regioselective Toxicity of Hydroxychrysenes in Embryos of Japanese Medaka (Oryzias latipes)
Tanabe, Philip; Pampanin, Daniela Maria; Tiruye, Hiwot Minwuyelet; Jørgensen, Kåre Bredeli; Hammond, Rachel; Gadepalli, Rama S.; Rimoldi, John M.; Schlenk, Daniel (Peer reviewed; Journal article, 2022)Oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) are ubiquitous contaminants that can be formed through oxidation of parent PAHs. Our previous studies found 2-hydroxychrysene (2-OHCHR) to be significantly more toxic ... -
Substituted Two- To Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a
Lille-Langøy, Roger; Jørgensen, Kåre Bredeli; Goksøyr, Anders; Pampanin, Daniela Maria; Sydnes, Magne Olav; Karlsen, Odd André (Peer reviewed; Journal article, 2021)Polycyclic aromatic hydrocarbons (PAHs) are among the most toxic and bioavailable components found in petroleum and represent a high risk to aquatic organisms. The aryl hydrocarbon receptor (Ahr) is a ligand-activated ... -
Synthesis of Phenacene−Helicene Hybrids by Directed Remote Metalation
Kancherla, Sindhu; Jørgensen, Kåre Bredeli (Peer reviewed; Journal article, 2020-08)Polycyclic aromatic hydrocarbons (PAHs) with six and seven rings were synthesized via directed metalation and cross-coupling of chrysenyl N,N-diethyl carboxamides with o-tolyl and methylnaphthalenyl derivatives. In the ...