Blar i Vitenskapelige publikasjoner (TN-IKBM) på forfatter "van der Giezen, Mark"

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    • Anaerobic Fungi: Past, Present, and Future 

      Hess, Matthias; Paul, Shyam S.; Puniya, Anil K.; van der Giezen, Mark; Shaw, Claire; Edwards, Joan E.; Fliegerova, Katerina (Peer reviewed; Journal article, 2020-10)
      Anaerobic fungi (AF) play an essential role in feed conversion due to their potent fiber degrading enzymes and invasive growth. Much has been learned about this unusual fungal phylum since the paradigm shifting work of ...

    • The Asgard Archaeal-Unique Contribution to Protein Families of the Eukaryotic Common Ancestor Was 0.3% 

      Knopp, Michael; Stockhorst, Simon; van der Giezen, Mark; Garg, Sriram G; Gould, Sven B (Peer reviewed; Journal article, 2021-04)
      The identification of the asgard archaea has fueled speculations regarding the nature of the archaeal host in eukaryogenesis and its level of complexity prior to endosymbiosis. Here, we analyzed the coding capacity of 150 ...

    • Evolutionary analysis of cellular reduction and anaerobicity in the hyper-prevalent gut microbe Blastocystis 

      Záhonová, Kristína; Low, Ross S.; Warren, Christopher J.; Cantoni, Diego; Herman, Emily K.; Yiangou, Lyto; Ribeiro, Cláudia A.; Phanprasert, Yasinee; Brown, Ian R.; Rueckert, Sonja; Baker, Nicola L.; Tachezy, Jan; Betts, Emma L.; Gentekaki, Eleni; van der Giezen, Mark; Clark, C. Graham; Jackson, Andrew P.; Dacks, Joel B.; Tsaousis, Anastasios D. (Peer reviewed; Journal article, 2023)
      Blastocystis is the most prevalent microbial eukaryote in the human and animal gut, yet its role as commensal or parasite is still under debate. Blastocystis has clearly undergone evolutionary adaptation to the gut environment ...

    • Further insight into the genetic diversity of Entamoeba coli and Entamoeba hartmanni 

      Stensvold, Christen Rune; Ascuña-Durand, Kasandra; Chihi, Amal; Belkessa, Salem; Kurt, Özgür; El-Badry, Ayman; van der Giezen, Mark; Clark, C. Graham (Peer reviewed; Journal article, 2022)
      Despite the species' wide distribution, studies of the genetic diversity within Entamoeba coli and Entamoeba hartmanni remain limited. In the present study, we provide further insight into the genetic diversity of both ...

    • Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri 

      Herman, Emily K.; Greninger, Alex; van der Giezen, Mark; Ginger, Michael L.; Ramirez-Macias, Inmaculada; Miller, Haylea C.; Morgan, Matthew J.; Tsaousis, Anastasios D.; Velle, Katrina; Vargova, Romana; Zahonova, Kristina; Najle, Sebastian Rodrigo; MacIntyre, Georgina; Muller, Norbert; Wittwer, Mattias; Zysset-Burri, Denise C.; Elias, Marek; Slamovits, Claudio H.; Weirauch, Matthew T.; Fritz-Laylin, Lilian; Marciano-Cabral, Francine; Puzon, Geoffrey J.; Walsh, Tom; Chiu, Charles; Dacks, Joel B. (Peer reviewed; Journal article, 2021)
      Background The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of brain material ...

    • Highly thermostable carboxylic acid reductases generated by ancestral sequence reconstruction 

      Thomas, Adam; Cutlan, Rhys; Finnigan, William; van der Giezen, Mark; Harmer, Nicholas (Peer reviewed; Journal article, 2019)
      Carboxylic acid reductases (CARs) are biocatalysts of industrial importance. Their properties, especially their poor stability, render them sub-optimal for use in a bioindustrial pipeline. Here, we employed ancestral ...

    • Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions 

      Vanhatalo, Anni; L’Heureux, Johanna E.; Kelly, James; Blackwell, Jamie; Wylie, Lee; Fulford, Jonathan; Winyard, Paul; Williams, David; van der Giezen, Mark; Jones, Andrew (Peer reviewed; Journal article, 2021)
      Many oral bacteria reduce inorganic nitrate, a natural part of a vegetable-rich diet, into nitrite that acts as a precursor to nitric oxide, a regulator of vascular tone and neurotransmission. Aging is hallmarked by reduced ...

    • Stool Microbiota Diversity Analysis of Blastocystis-Positive and Blastocystis-Negative Individuals 

      Stensvold, Christen Rune; Sørland, Brede Aksdal; Berg, Rebecca P. K. D.; Andersen, Lee O’Brien; van der Giezen, Mark; Bowtell, Joanna L.; El-Badry, Ayman A.; Belkessa, Salem; Kurt, Özgür; Nielsen, Henrik Vedel (Peer reviewed; Journal article, 2022)
      Blastocystis is a unicellular eukaryote found in the gastrointestinal tract of both human and other animal hosts. The clinical significance of colonic Blastocystis colonization remains obscure. In this study, we used ...

    • Understanding the role of the shrimp gut microbiome in health and disease 

      Holt, Corey; Bass, David; Stentiford, Grant D.; van der Giezen, Mark (Peer reviewed; Journal article, 2020-04)
      With rapid increases in the global shrimp aquaculture sector, a focus on animal health during production becomes ever more important. Animal productivity is intimately linked to health, and the gut microbiome is becoming ...