Blar i Studentoppgaver (TN-IKBM) på forfatter "Bjelland, Svein"
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Excision of 5-hydroxymethyluracil in single-stranded DNA by hSMUG1 requires Ser26 and/or Glu35 and Pro240
Bærheim, Trond (Master thesis, 2021)The integrity of the genetic material of all organisms is assaulted continuously by a multitude of endogenous and exogenous agents throughout its lifetime, where the DNA bases of the genetic code may be altered if not ... -
hUNG activity for uracil in bubble and R-loop DNA
Mehanna, Shimaa (Master thesis, 2021)Uracil, a common base in RNA, may arise in cellular DNA by cytosine deamination or during replication through the misincorporation of deoxyuridine monophosphate instead of thymidine monophosphate. Repair of uracil is ... -
Molecular biology of modified DNA bases
Aanderaa, Inger Djuve (Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-08)The cell has several mechanisms for repairing DNA damages, and it has been widely accepted that the base excision repair (BER) pathway is the main repair mechanism for small non helix distorting damages caused by oxidation. ... -
Replacing Pro240 with Gly in hSMUG1 increases uracil excision in R-loop but abolish 5-hydroxymethyluracil excision in ssDNA
Lorentsen, Celine (Master thesis, 2021)Deamination and oxidation of pyrimidines are two major spontaneously damaging events in DNA. The DNA glycosylase SMUG1 initiates repair of deaminated or oxidized bases by breaking the glycosidic bond between the damaged ... -
Uracil-excising activity of hSMUG1 in bubble and R-loop DNA
Ruales, Cyrell Ann (Master thesis, 2021)Uracil arises in cellular DNA by hydrolytic cytosine (C) deamination and by erroneous repli-cative incorporation of deoxyuridine monophosphate opposite adenine. The former event is devastating by generation of C thymine ...