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Dopaminregulert DOPA homeostase og nevrodegenerative forstyrrelser

Bø, Lene Victoria
Bachelor thesis
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URI
https://hdl.handle.net/11250/2774265
Date
2021
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  • Studentoppgaver (TN-IKBM) [313]
Abstract
Velfungerende mekanismer for homeostase leder til et robust homeostatisk dopaminerg system. Ett ikke-funksjonelt homeostatisk dopaminerg system er kjent for å være assosiert med nevrodegenerative lidelser som Parkinsons sykdom (PD). I denne undersøkelsen av en robust homeostase, blir dopamin (DA) sin sensitive funksjonalitet undersøkt, som består av balansen mellom syntese, frigjøring, lagring, gjenopptak og metabolisme, samt dens rolle som en negativ tilbakemeldingsregulator av dihydroksyfenylalanin (DOPA). I beregningene fokuserer jeg på kontrollen DA har over de regulerte molekylene i reaksjonen, samt demonsterer jeg virkningen av DOPA som medisinering av PD.
 
Well-functioning homeostatic mechanisms lead to a robust homeostatic dopaminergic system. The dysfunction of this system is known to be associated with neurodegenerative disorders like Parkinson’s disease (PD). In this examination of a robust homeostasis, dopamine (DA) is examined by its functionality of the gentle balance between synthesis, release, storage, re-uptake, and metabolism, as well as its role as a negative feedback regulator of dihydroxyphenylalanine (DOPA). In the computations I focus on the control DA has of the regulated species in the pathway, as well as demonstrating the impact of DOPA as a medication of PD.
 
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uis

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