Blar i Department of Chemistry, Bioscience and Environmental Engineering (TN-IKBM) på tittel
Viser treff 110-129 av 498
-
Development of LC-MS/MS method for analysing immunosuppressants in whole blood for the purpose of TDM, with the novel application of SALLE in the sample preparation
(Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020-07-06)The laboratory for Medical Biochemistry at Stavanger University Hospital (SUS) needed a new method for analysing tacrolimus, sirolimus, everolimus and cyclosporin A. A method was developed using the analytical principles ... -
Development of Naval Controlling Loops for Primary Sludge Thickening Process at SNJ Wastewater Treatment Plant
(Master thesis, 2021)The solid concentration of primary sludge is increased by thickening process of the wastewater treatment plant (WWTP). At SNJ WWTP, rotary drum thickener is used to thicken primary sludge and expected to obtain 5 ±1 % ... -
Development of new Corrosion Inhibitors
(Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-06-15)Pipelines are an essential part of the oil ang gas industry as they are the main means of transportation. As the offshore technology advances, subsea pipelines are being operated in more demanding environments. In field ... -
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
(Peer reviewed; Journal article, 2021-07)The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters ... -
Diastereoselectivity in Anomeric O-alkylation Glycosylation
(PhD thesis UiS;, Doctoral thesis, 2021-02)Biosynth AS used anomeric O-alkylation of α-haloacetophenones in their patented total synthesis of anthocyanins from 2006. There were, however, several challenges with stereoselectivity and yields when performing this ... -
Differential transcript usage in the Parkinson’s disease brain
(Peer reviewed; Journal article, 2020)Studies of differential gene expression have identified several molecular signatures and pathways associated with Parkinson’s disease (PD). The role of isoform switches and differential transcript usage (DTU) remains, ... -
Directed ortho-Metalation and Anionic ortho-Fries Rearrangement of Polycyclic Aromatic O-Carbamates: Regioselective Synthesis of Substituted Chrysenes
(Peer reviewed; Journal article, 2018-03)A general method for the regioselective synthesis of a series of ortho-substituted chrysenyl N,N-diethyl-O-carbamates by the directed ortho-metalation (DoM) strategy is reported. The starting O-carbamates were prepared ... -
Distinct Clades of Protein Phosphatase 2A Regulatory B’/B56 Subunits Engage in Different Physiological Processes
(Peer reviewed; Journal article, 2023-07)Protein phosphatase 2A (PP2A) is a strongly conserved and major protein phosphatase in all eukaryotes. The canonical PP2A complex consists of a catalytic (C), scaffolding (A), and regulatory (B) subunit. Plants have three ... -
Distinct Gene Expression Profiles of Matched Primary and Metastatic Triple-Negative Breast Cancers
(Peer reviewed; Journal article, 2022)Background: Although triple-negative breast cancer (TNBC) is associated with an increased risk of recurrence and metastasis, the molecular mechanisms underlying metastasis in TNBC remain unknown. To identify transcriptional ... -
Divergent Synthesis of Indolo[3,2- c]quinolines, Neocryptolepines and Related Tetracyclic Ring-Systems Containing Promising Biological Activities
(PhD thesis UiS;, Doctoral thesis, 2022)Malaria is a devastating tropical disease, claiming approximately 627 000 lives in 2020. Due to the appearance of resistance towards artemisinin-based therapies, the discovery of novel treatments are of paramount ... -
DNA damage and health effects in juvenile haddock (Melanogrammus aeglefinus) exposed to PAHs associated with oil-polluted sediment or produced water
(Peer reviewed; Journal article, 2020)The research objective was to study the presence of DNA damages in haddock exposed to petrogenic or pyrogenic polyaromatic hydrocarbons (PAHs) from different sources: 1) extracts of oil produced water (PW), dominated by ... -
DOPA Homeostasis by Dopamine: A Control-Theoretic View
(Peer reviewed; Journal article, 2021-11)Dopamine (DA) is an important signal mediator in the brain as well as in the periphery. The term “dopamine homeostasis” occasionally found in the literature refers to the fact that abnormal DA levels can be associated with ... -
Dopamin som nevrotransmitter – en bioinformatisk analyse av dopamintransporteren, samt et innblikk i samme molekyls kinetikk.
(Bachelor thesis, 2022)Dopamin er et viktig hormon i kroppen, og er med på å styre blant annet følelser, bevegelse og kognitive mekanismer. Et av molekylene som er ansvarlig for å regulere dopaminnivået i hjernen, kalles Dopamintransporteren ... -
Dopamine as a Homeostatic Regulator of Levodopa and its contribution to Neurological Disorders
(Bachelor thesis, 2021)Homeostasis is the tendency to maintain a relatively constant internal environment. The concept of homeostasis is essential when it comes to understanding organisms and their ability to adapt when faced with external ... -
Dopaminregulert DOPA homeostase og nevrodegenerative forstyrrelser
(Bachelor thesis, 2021)Velfungerende mekanismer for homeostase leder til et robust homeostatisk dopaminerg system. Ett ikke-funksjonelt homeostatisk dopaminerg system er kjent for å være assosiert med nevrodegenerative lidelser som Parkinsons ... -
Dynamics of Hypercycles in Viral Replication and Investigations of positive feedback loops
(Master thesis, 2021)Positive feedbacks are of importance in biochemical processes, including also replication mechanisms. Positive feedback is a process that takes place in a feedback loop that amplifies small changes. It means that the impact ... -
Dysfunction of Protein Homeostasis: Factors in uencing the Formation of alpha - Synuclein (Lewy Bodies) in Arabidopsis thaliana plants
(Masteroppgave/UIS-TN-IKBM/2019;, Master thesis, 2019-06-15)BACKGROUND:Protein homeostasis or proteostasis under the conscious control of a network of proteins including chaperones, transporters, ubiquitin-dependent proteasome control the proper expression, folding, translocation ... -
Early constipation predicts faster dementia onset in Parkinson's disease
(Peer reviewed; Journal article, 2021-05)Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s ... -
Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease
(Peer reviewed; Journal article, 2022)Idiopathic Parkinson’s disease (iPD) is characterized by degeneration of the dopaminergic substantia nigra pars compacta (SNc), typically in the presence of Lewy pathology (LP) and mitochondrial respiratory complex I (CI) ... -
An economic and environmental analysis of greenhouse tomato production in Norway using a model-based technique
(PhD thesis UiS;, Doctoral thesis, 2022-12)The growing global population levels and the resulting increasing demands for food has put a lot of pressure on the food production systems and made the agricultural sector highly energy-intensive. The intensification in ...