Browsing Department of Chemistry, Bioscience and Environmental Engineering (TN-IKBM) by Author "Ruoff, Peter"
Now showing items 1-20 of 25
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Alexeeva, M., Moen, M.N., Grøsvik, K. et al (2018) Excision of uracil from DNA by hSMUG1 includes strand incision and processing.
Moen, Marivi Nabong; Grøsvik, Kristin; Kirpekar, Finn; Tesfahun, Almaz Nigatu; Ruoff, Peter; Klungland, Arne; Bjelland, Svein (Journal article; Peer reviewed, 2018-11)Uracil arises in DNA by hydrolytic deamination of cytosine (C) and by erroneous incorporation of deoxyuridine monophosphate opposite adenine, where the former event is devastating by generation of C → thymine transitions. ... -
Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein
Tesfahun, Almaz Nigatu; Alexeeva, Marina; Tomkuvienė, Miglė; Arshad, Aysha; Guragain, Prashanna; Klungland, Arne; Klimašauskas, Saulius; Ruoff, Peter; Bjelland, Svein (Peer reviewed; Journal article, 2021-06)DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions. The most ... -
An amplified derepression controller with multisite inhibition and positive feedback
Drobac, Gorana; Waheed, Qaiser; Heidari, Behzad; Ruoff, Peter (Peer reviewed; Journal article, 2021-03)How organisms are able to maintain robust homeostasis has in recent years received increased attention by the use of combined control engineering and kinetic concepts, which led to the discovery of robust controller motifs. ... -
Bioeconomic evaluation of extended season and year-round tomato production in Norway using supplemental light
Naseer, Muhammad; Persson, Tomas; Righini, Isabela; Stanghellini, Cecilia; Maessen, Hendricus; Ruoff, Peter; Verheul, Michel (Peer reviewed; Journal article, 2022)CONTEXT For high latitude countries like Norway, one of the biggest challenges associated with greenhouse production is the limited availability of natural light and heat, particularly in winters. This can be addressed ... -
Coherent feedback leads to robust background compensation in oscillatory and non-oscillatory homeostats
Nygård, Melissa; Ruoff, Peter (Peer reviewed; Journal article, 2023-08)When in a reaction kinetic integral controller a step perturbation is applied besides a constant background, the concentration of a controlled variable (described as A) will generally respond with decreased response ... -
DOPA Homeostasis by Dopamine: A Control-Theoretic View
Kleppe, Rune; Waheed, Qaiser; Ruoff, Peter (Peer reviewed; Journal article, 2021-11)Dopamine (DA) is an important signal mediator in the brain as well as in the periphery. The term “dopamine homeostasis” occasionally found in the literature refers to the fact that abnormal DA levels can be associated with ... -
Dopamine as a Homeostatic Regulator of Levodopa and its contribution to Neurological Disorders
Afradi, Olga (Bachelor thesis, 2021)Homeostasis is the tendency to maintain a relatively constant internal environment. The concept of homeostasis is essential when it comes to understanding organisms and their ability to adapt when faced with external ... -
Dopaminregulert DOPA homeostase og nevrodegenerative forstyrrelser
Bø, Lene Victoria (Bachelor thesis, 2021)Velfungerende mekanismer for homeostase leder til et robust homeostatisk dopaminerg system. Ett ikke-funksjonelt homeostatisk dopaminerg system er kjent for å være assosiert med nevrodegenerative lidelser som Parkinsons ... -
An economic and environmental analysis of greenhouse tomato production in Norway using a model-based technique
Naseer, Muhammad (PhD thesis UiS;, Doctoral thesis, 2022-12)The growing global population levels and the resulting increasing demands for food has put a lot of pressure on the food production systems and made the agricultural sector highly energy-intensive. The intensification in ... -
The escherichia coli alkA gene is activated to alleviate mutagenesis by an oxidized deoxynucleoside
Grøsvik, Kristin; Tesfahun, Almaz Nigatu; Muruzábal-Lecumberri, Izaskun; Haugland, Gyri Teien; Leiros, Ingar; Ruoff, Peter; Kvaløy, Jan Terje; Knævelsrud, Ingeborg; Ånensen, Hilde; Alexeeva, Marina; Sato, Kousuke; Matsuda, Akira; Alseth, Ingrun; Klungland, Arne; Bjelland, Svein (Peer reviewed; Journal article, 2020)The cellular methyl donor S-adenosylmethionine (SAM) and other endo/exogenous agents methylate DNA bases non-enzymatically into products interfering with replication and transcription. An important product is 3-methyladenine ... -
Excision of 5-hydroxymethyluracil in single-stranded DNA by hSMUG1 requires Ser26 and/or Glu35 and Pro240
Bærheim, Trond (Master thesis, 2021)The integrity of the genetic material of all organisms is assaulted continuously by a multitude of endogenous and exogenous agents throughout its lifetime, where the DNA bases of the genetic code may be altered if not ... -
Frequency switching between oscillatory homeostats and the regulation of p53
Ruoff, Peter; Nishiyama, Nobuaki (Peer reviewed; Journal article, 2020-05)Homeostasis is an essential concept to understand the stability of organisms and their adaptive behaviors when coping with external and internal assaults. Many hormones that take part in homeostatic control come in ... -
Homeostasis at different backgrounds: The roles of overlayed feedback structures in vertebrate photoadaptation
Grini, Jonas V.; Nygård, Melissa; Ruoff, Peter (Peer reviewed; Journal article, 2023)We have studied the resetting behavior of eight basic integral controller motifs with respect to different but constant backgrounds. We found that the controllers split symmetrically into two classes: one class, based on ... -
Homeostasis by depression kinetics with multisite inhibition and positive feedback
Drobac, Gorana (Masteroppgave/UIS-TN-IKBM/2020;, Master thesis, 2020)In order to survive all living organisms must, to some extent, be able to adapt to the changes in environment.In recent years there have been proposed different controller motifs that are used to explain how does the ... -
Homeostatic controllers compensating for growth and perturbations
Ruoff, Peter; Agafonov, Oleg; Tveit, Daniel Myklatun; Thorsen, Kristian; Drengstig, Tormod (Journal article; Peer reviewed, 2019-08)Cells and organisms have developed homeostatic mechanisms which protect them against a changing environment. How growth and homeostasis interact is still not well understood, but of increasing interest to the molecular and ... -
Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren's syndrome
Bårdsen, Kjetil; Brede, Cato; Kvivik, Ingeborg; Kvaløy, Jan Terje; Jonsdottir, Kristin; Tjensvoll, Anne Bolette; Ruoff, Peter; Omdal, Roald (Peer reviewed; Journal article, 2019)Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ... -
Interleukin-1β, heat shock protein 90α, and hypocretin-1 in chronic fatigue
Bårdsen, Kjetil (PhD thesis UiS;505, Doctoral thesis, 2020-09)Background: Fatigue, defined as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion, is a phenomenon many people have experienced in connection with infections such as influenza, Epstein-Barr ... -
Kinetics and mechanisms of catalyzed dual-E (antithetic) controllers
Waheed, Qaiser; Zhou, Huimin; Ruoff, Peter (Peer reviewed; Journal article, 2022)Homeostasis plays a central role in our understanding how cells and organisms are able to oppose environmental disturbances and thereby maintain an internal stability. During the last two decades there has been an increased ... -
Life cycle assessment of tomato production for different production strategies in Norway
Naseer, Muhammad; Persson, Tomas; Hjelkrem, Anne-Grete Roer; Ruoff, Peter; Verheul, Michel (Peer reviewed; Journal article, 2022)The availability of fresh vegetables grown in greenhouses under controlled conditions throughout the year has given rise to concerns about their impact on the environment. In high latitude countries such as Norway, greenhouse ... -
Listeria monocytogenes in Norwegian fish farms from September to January
Zaremba, Sandra (Masteroppgave/UIS-TN-IKBM/2018;, Master thesis, 2018-06)The Norwegian food industry is best known for salmon production and distribution to over 70 countries. Salmon processing factories are susceptible to the establishment of the pathogen bacterium Listeria monocytogenes, which ...