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Stochastic simulations as a tool for assessing signal fidelity in gene expression in synthetic promoter design
(Peer reviewed; Journal article, 2021-07)The design and development of synthetic biology applications in a workflow often involve connecting modular components. Whereas computer-aided design tools are picking up in synthetic biology as in other areas of engineering, ... -
Stool Microbiota Diversity Analysis of Blastocystis-Positive and Blastocystis-Negative Individuals
(Peer reviewed; Journal article, 2022)Blastocystis is a unicellular eukaryote found in the gastrointestinal tract of both human and other animal hosts. The clinical significance of colonic Blastocystis colonization remains obscure. In this study, we used ... -
A strategy to characterize chlorophyll protein interaction in LIL3
(Peer reviewed; Journal article, 2019)The function of proteins is at large determined by cofactors selectively bound to protein structure. Without chlorophyll specifically bound to protein, light harvesting and photosynthesis would not be possible. The binding ... -
Study of the long-finned pilot whale (Globicephala melas) bile content - An indicator of ocean health
(Peer reviewed; Journal article, 2023)Globicephala melas has been harvested in the Faroe Islands for centuries. Given the distances travelled by this species, tissue/body fluid samples represent unique matrices to be considered as an integration of environmental ... -
Subcellular localization and therapeutic efficacy of polymeric micellar nanoparticles encapsulating bedaquiline for tuberculosis treatment in zebrafish
(Peer reviewed; Journal article, 2023)The combination drug regimens that have long been used to treat tuberculosis (TB), caused by Mycobacterium tuberculosis, are fraught with problems such as frequent administration, long duration of treatment, and harsh ... -
Substituted Two- To Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a
(Peer reviewed; Journal article, 2021)Polycyclic aromatic hydrocarbons (PAHs) are among the most toxic and bioavailable components found in petroleum and represent a high risk to aquatic organisms. The aryl hydrocarbon receptor (Ahr) is a ligand-activated ... -
Sulfur‐Decorated Ni−N−C Catalyst for Electrocatalytic CO2 Reduction with Near 100 % CO Selectivity
(Peer reviewed; Journal article, 2022-08)Developing highly efficient electrocatalysts for electrochemical CO2 reduction (ECR) to value-added products is important for CO2 conversion and utilization technologies. In this work, a sulfur-doped Ni−N−C catalyst is ... -
Synergistic Gas Hydrate and Corrosion Inhibition Using Maleic Anhydride: N-Isopropylmethacrylamide Copolymer and Small Thiols
(Peer reviewed; Journal article, 2023)Kinetic gas hydrate inhibitors (KHIs) are often used in combination with film-forming corrosion inhibitors (CIs) in oilfield production flow lines. However, CIs can be antagonistic to KHI performance. In this study, maleic ... -
Synergy Effect Study of Poly(N-isoacrylamide) with Tetra Butyl Phosphonium Bromide on Methane Hydrate Formation
(Journal article, 2019)Natural gas hydrate plugging is one of the costly and challenging problems for the oil and gas industry, especially for subsea fields. One way to prevent gas hydrate formation at low cost is the use of low-dosage hydrate ... -
Synthesis and Antiscaling Evaluation of Novel Hydroxybisphosphonates for Oilfield Applications
(Peer reviewed; Journal article, 2021)Organophosphorous compounds are still widely used as potential scale inhibitors in the upstream oil and gas industry, particularly in squeeze treatments as they have good adsorption properties on rock and are easily ... -
Synthesis and Evaluation of the Tetracyclic Ring-System of Isocryptolepine and Regioiso-Mers for Antimalarial, Antiproliferative and Antimicrobial Activities
(Peer reviewed; Journal article, 2021-05)A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the ... -
Synthesis and Investigation of Polymers of 2‑Methacrylamido-caprolactam as Kinetic Hydrate Inhibitors
(Peer reviewed; Journal article, 2020-05)Poly(N-vinylcaprolactam) (PVCap) and related copolymers have been used as kinetic hydrate inhibitors (KHIs) for over 25 years to combat gas hydrate formation in oil and gas field production flow lines. The caprolactam ... -
Synthesis and Study of Modified Polyaspartic Acid Coupled Phosphonate and Sulfonate Moieties As Green Oilfield Scale Inhibitors
(Peer reviewed; Journal article, 2021)The petroleum industry has strived for several years to explore environmentally friendly scale inhibitors with no acute environmental impact. Well-known industrial biodegradable polyaspartic acid is widely used as a potent ... -
Synthesis of an Alleged Byproduct Precursor in Iodixanol Preparation
(Peer reviewed; Journal article, 2018-07)N1,N3-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-(oxiran-2-ylmethyl)acetamido)isophthalamide (1), the alleged precursor of several minor byproducts formed when the X-ray contrast agent iodixanol is synthesized from ... -
Synthesis of Phenacene−Helicene Hybrids by Directed Remote Metalation
(Peer reviewed; Journal article, 2020-08)Polycyclic aromatic hydrocarbons (PAHs) with six and seven rings were synthesized via directed metalation and cross-coupling of chrysenyl N,N-diethyl carboxamides with o-tolyl and methylnaphthalenyl derivatives. In the ... -
Synthesis of the Hexahydropyrrolo‐[3,2‐c]‐quinoline Core Structure and Strategies for Further Elaboration to Martinelline, Martinellic Acid, Incargranine B, and Seneciobipyrrolidine
(Peer reviewed; Journal article, 2021-01)Natural products are rich sources of interesting scaffolds possessing a plethora of biological activity. With the isolation of the martinella alkaloids in 1995, namely martinelline and martinellic acid, the pyrrolo[3,2‐c]quinoline ... -
Synthesis of trans-dihydronaphthalene-diol and evaluation of their use as standards for PAH metabolite analysis in fish bile by GC-MS
(Peer reviewed; Journal article, 2020-05)Phenols and trans-1,2-dihydro-1,2-diols are metabolites commonly formed in vivo in fish upon exposure to polycyclic aromatic hydrocarbons (PAHs). These metabolites are excreted via the bile and gas chromatography-mass ... -
A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease
(Peer reviewed; Journal article, 2021-07)There is great heterogeneity in both the clinical presentation and rate of disease progression among patients with Parkinson’s disease (PD). This can pose prognostic difficulties in a clinical setting, and a greater ... -
A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment
(Peer reviewed; Journal article, 2021)Background In colon cancer, the location and density of tumor-infiltrating lymphocytes (TILs) can classify patients into low and high-risk groups for prognostication. While a commercially available ‘Immunoscore®’ exists, ... -
The crystal structure of haemoglobin from Atlantic cod
(Journal article; Peer reviewed, 2019-06)The crystal structure of haemoglobin from Atlantic cod has been solved to 2.54 Å resolution. The structure consists of two tetramers in the crystallographic asymmetric unit. The structure of haemoglobin obtained from one ...