1,4-Dideoxy-1,4-imino‑D‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitors

Haarr, Marianne Bore; Lopez, Oscar; Pejov, Ljupcho; Fernandez-Bolanos, Jose G.; Lindback, Emil; Sydnes, Magne Olav
Peer reviewed, Journal article
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https://hdl.handle.net/11250/2671187
Date
2020-07
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Original version
Haarr, M.B., Lopez, O., Pejov, L. et al. (2020) 1,4-Dideoxy-1,4-imino‑D‑arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α‑Mannosidase Inhibitors. ACS Omega. 2020, 5(29), 18507-18514.   10.1021/acsomega.0c02466
Abstract
The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (Ki values ranging from 0.23 to 1.4 μM).
Publisher
American Chemical Society
Journal
ACS Omega
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